Circadian rhythm is an important component of mammalian physiology and plays a large role in sleep-wake cycles, core body temperature, hormone balance and eating patterns.
Disturbances with circadian rhythm are seen in the early stages of Alzheimer’s Disease. One type of circadian disturbance is known as Sundowning Syndrome, which is a neurological phenomenon that occurs in about 20% of people with Alzheimer’s1 and is presented as confusion, agitation and anxiety occurring in the late afternoon and continuing through the night.
Indicators of AD while studying circadian rhythm include:
- Increased evening activity
- Alterations in core body temperature
- Eating habits and alterations in fasting/feeding cycles
Implantable telemetry is the only method available which can simultaneously monitor core body temperature and activity in animals.
Google Scholar indexes 104 articles citing AD, Circadian Rhythm, and DSI