Monitoring Tumor-Induced Bone Pressure
Bone tissue is one of the most common sites of metastasis and occurs when cancer cells from a primary tumor, typically breast, lung or prostate, migrate to the bone through the blood stream or lymphatic system. Secondary bone cancer, caused by metastasis, is more common than primary. Currently, there is no cure for bone metastasis, only treatment that reduces its progression.
Animal models used to measure bone pressure range from mice to large animals. The most common technique used to induce tumor associated bone pressure is to inject tumor cells directly into the intramedullary cavity. Researchers are also studying naturally occurring bone metastasis by injecting cancer cells into the mammary fat pad for breast cancer or directly into the prostate. Left ventricular intracardiac injection is also a popular choice and can be used to determine distal metastasis as well as tumor cell circulation. By measuring tumor pressure within the bone, researchers are finding that the increased pressure caused by tumor growth promotes osteocyte secretion, leading to increased metastasis. Methods to obtain bone pressure include the insertion of a DSI pressure sensor inside the intramedullary cavity of the bone.