Metabolism and Food/Drink Intake

Metabolic phenotyping is the study of how an organism generates, stores, and utilizes energy in states of disease and health. Typical assessments include respiratory metabolism (RQ or RER) through the indirect calorimetry technique, food/drink intake analysis, and spontaneous activity. A more comprehensive understanding of an animal’s body mass phenotype is obtained by evaluating both respiratory metabolism and digestive efficiency through the analysis of urine and feces (waste collection). Measurements during forced exercise, such as treadmill running, provide additional insight into aerobic capacity (VO2max) and ability to adapt under physical challenge.

Oxylet Pro

Common Applications

  • Metabolic Diseases
  • Obesity
  • Cancer
  • Cachexia
  • Diabetes
  • Cardiovascular Diseases
  • Exercise Physiology
  • Chronobiology/Circadian Rhythm

Combined Approaches

Combine the OxyletPro indirect calorimetry physiocage and treadmill systems with DSI telemetry solutions for a more comprehensive, holistic picture of whole animal cardiovascular and metabolic physiology. Complementary physiology measurements include body temperature, heart rate, blood pressure, blood glucose and more.



Recent References

OxyletPro Physiocage
1. Kim MY, Lee K, Shin HI. et al. Metabolic activities affect femur and lumbar vertebrae remodeling, and anti-resorptive risedronate disturbs femoral cortical bone remodeling. Exp Mol Med. 2021 Jan;53(1):103-114.

2. Kilonzo VW, Sasuclark AR, Torres DJ. et al. Juvenile Selenium Deficiency Impairs Cognition, Sensorimotor Gating, and Energy Homeostasis in Mice. Front Nutr. 2021 May 7;8:667587.

3. Yang J, Zhang Y, Pan Y. et al. The Protective Effect of 1,25(OH)2D3 on Myocardial Function is Mediated via Sirtuin 3-Regulated Fatty Acid Metabolism. Front Cell Dev Biol. 2021 Apr 26;9:627135.

4. Fujimoto BA, Young M, Nakamura N. et al. Disrupted glucose homeostasis and skeletal muscle-specific glucose uptake in an exocyst knockout mouse model. J Biol Chem. 2021 Feb 26;296:100482.

OxyletPro Treadmill
5. Paes L et al. (2020) Effects of moderate and high intensity isocaloric aerobic training upon microvascular reactivity and myocardial oxidative stress in rats. PLoS One. 2020; 15:e0218228.

6. Terra MF et al. (2019) Physical exercises decreases thrombus and neointima formation in atherosclerotic mice. Thromb Res. 2019; 175:21-31.

7. Motta VF et al. (2019) Browning is activated in the subcutaneous white adipose tissue of mice metabolically challenged with a high-fructose diet submitted to high-intensity interval training. J Nutr Biochem. 2019; 70:164-173.

8. Raposo HF, Forsythe P, Chausse B, Castelli JZ, Moraes-Vieira PM, Nunes VS, Oliveira HCF. Novel role of cholesteryl ester transfer protein (CETP): attenuation of adiposity by enhancing lipolysis and brown adipose tissue activity. Metabolism. 2021 Jan;114:154429.

9. Fructuoso M, Gu YC, Kassis N. et al. Ethanol-Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A. Mol Neurobiol. 2020 Jul;57(7):3195-3205.

10. Fructuoso M, Espinosa-Carrasco J, Erb I. et al. Protocol for Measuring Compulsive-like Feeding Behavior in Mice. Bio Protoc. 2019 Jul 20;9(14):e3308.