Spinal Cord Injury




Approximately 250,000 - 500,000 People Suffer a
Spinal Cord Injury (SCI) Every Year



There is no cure and many will experience lifelong acute and chronic health difficulties 


Spinal Cord Injury, SCI




DSI Solutions Help Researchers
Understand and Treat Spinal Cord Injury

The following areas of research and commonly collected biomarkers in preclinical studies are used to improve therapeutic outcomes into the clinic and help advance patient quality of life. 








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For an overview of the most commonly referenced SCI models and examples of their use, download our free white paper:  Research Models of Spinal Cord Injury







Cardiovascular

Cardiac dysfunction is common in the acute and chronic phases of high level spinal cord injury. Complications include autonomic dysreflexia, hypotension, orthostatic intolerance, bradycardia, cardiomyopathy, and increased risk for coronary heart disease. 


Common Endpoints


Blood Pressure

Heart Rate

Pressure-Volume Loops

Blood Flow

Electrocardiogram



Google Scholar Indexes 109 Publications Citing DSI, Cardiovascular and Spinal Cord Injury









Respiratory

Respiratory complications can occur in Thoracic 12 - Cervical 1 SCI and can range from weakened abdominal muscles to complete ventilation. Pulmonary issues are the number one cause of morbidity and mortality in the first year post spinal cord injury. 


Common Endpoints


Breathing Frequency

 Inspiratory and Expiratory Duration

 Peak Airflow Rates

 Tidal and Expiratory Reserve Volume

 Volume and Functional Residual Capacity

Respiratory Muscle Function

Lung and Chest Wall Compliance

 


Google Scholar Indexes 136 Publications Citing DSI's Buxco Respiratory Solutions and Spinal Cord Injury









Behavioral Testing

Functional assessments are commonly done in SCI research. Behavioral and mobility experiments allow researchers to evaluate the extent of injury, identify rehabilitation and recovery methods, and evaluate treatment options. There are a variety of behavioral tests that are used in SCI research.


Common Endpoints


Task Performance

Electromyogram (EMG)

Activity and Ambulation

Pain and Sensation

Functional Recovery

Strength 

Balance




*Behavioral solutions are available from our Harvard Bioscience sister brands Panlab and Coulbourn Instruments. Reach out to us to learn more about how to incorporate these solutions into your current research set-up. 

Google Scholar
290 Publications Citing Panlab and Spinal Cord Injury
162 Publications Citing Coulbourn and Spinal Cord Injury
45 Publications Citing DSI Spinal, Cord Injury and EMG










Sleep

Sleep disorders are commonly reported in patients following SCI and occur due to pain, circadian rhythm disturbances, breathing difficulties, abnormal leg movements, pharmacological effects, and depression. 


Common Endpoints


Electroencephalogram (EEG)

 Electromyogram (EMG)

Respiratory Rate

Tidal Volume

Temperature




Google Scholar Indexes 61 Publications Citing DSI, Spinal Cord Injury and Sleep









Temperature

Dysregulation of temperature control below the point of injury is common in patients with cervical and high thoracic injuries. Hyperthermic and hypothermic conditions can result in serious life threatening conditions if not recognized quickly enough. 


Common Endpoints


Core Body Temperature

Localized Temperature

Ambient Temperature

Activity

  

Google Scholar Indexes 137 Publications Citing DSI, Spinal Cord Injury and Temperature









Sexual Function

Sexual dysfunction after a SCI depends on location and severity of initial injury.  Many people report disturbances in sexual function, which can lead to a decreased quality of life.  


Common Endpoints


Activity

Penile Pressure

Penile Reflexes

 

  

Google Scholar Indexes 17 Publications Citing DSI, Spinal Cord Injury and Sexual Function