CBRN Defense


Scientific Overview of CBRN

CBRN (chemical, biological, radiological or nuclear) research aims to identify protective or defense measures that can be applied in situations where advanced research and development of medical countermeasures are necessary.

Research conducted to characterize medical interventions for humans follow the FDA’s Animal Rule addressing efficacy using animal models for translation of disease manifestations and potential treatments.  

Researchers are often interested in physiologic parameters to detect changes in fever, heart rate, respiration, sleep and seizure activities. Wireless physiological monitoring has established its position as a technology that enables researchers to acquire data on ambulatory animal models that closely represent human scenarios; thus, providing critical physiologic data not feasible via other methods. 

Gathering data to aid in the development of defense countermeasures to preserve human life, is trusted to advanced technologies provided by DSI.

  • Implantable telemetry increases safety for personnel by providing information remotely, and limiting human to subject interactions
  • Plethysmography solutions help researchers understand potential side effects when respiratory airways airways are the focus of interest

Using DSI technologies, researchers safely collect data for a complete physiologic view of animal models and the impact to physiologic changes during these important studies.

Methods and Parameters

Physiologic data is critical to understanding disease morphology and physiologic response for the establishment of treatment regimens for chemical, biological, radiation and nuclear countermeasures.

Parameters Commonly Measured by CBRN Researchers include assessment of respiratory function.  Implantable telemetry can be combined with chamber systems to collect cardiovascular, EEG, temperature, activity and respiratory function in a single system.

127

CBRN articles citing DSI telemetry in Google Scholar


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CBRN articles citing DSI respiratory systems Google Scholar


PhysioTel Digital large animal implants
DSI offers several different implant combinations to measure different parameters including pressure, biopotentials, temperature and activity. 

Learn more about PhysioTel Digital products.


L21 Implant


Ponemah Remote Notification
Convenient, automated alerts for subject-level and system-level conditions. Continuous physiologic monitoring should not need your undivided attention. Constantly checking data acquisition throughout the day, on weekends, or the middle of the night isn’t an efficient use of your time. Ponemah provides peace of mind by monitoring subject health and system functionality,notifying you when necessary.
 
Learn more about the Ponemah Remote Notification software feature
Remote Notification Email


PhysioTel large animal respiratory implant
This first-of-its-kind device, the D70-PCTR, is a versatile option for researchers with a need to monitor a pressure, biopotential, temperature, respiratory volume,  respiration rate and activity.

Learn more about the PhysioTel large animal respiratory implant
PCTR


Buxco respiratory exposure systems
DSI’s Buxco Mass Dosing Chambers are used to expose multiple subjects to an aerosol or gas when general dosing can be tolerated. For precise nose-only exposures, use the Inhalation Tower system.

Learn more about Buxco inhalation and exposure systems
Mass Dosing system

Continuous glucose telemetry implant

Continuous blood glucose monitoring can be used as a marker of damage or recovery for many models of chemical or radiation exposure.


Learn more about implantable glucose telemetry
Glucose Implant


Data analysis and report generation services
DSI delivers high-quality, customized, comprehensive reports for evaluation of: hemodynamics, heart rate variability, ECG interval quantification, arrhythmia detection, seizure detection, sleep scoring, blood pressure, respiration, temperature and activity that change from study to study and subject to subject. 

Learn more about data analysis and report generation services
data2


Pre-implantation services
The choice is yours: Surgeries performed at your location on your test subjects, or Pre-implanted animals are delivered to your location. 

Learn more about DSI's pre-implantation services 
scalpel2


Buxco inhalation dosing tower
For use with small animals, inhalation dosing towers ensure that simultaneous exposure of compounds or gases to the lungs of rodents is well controlled, consistent, and defined.

Learn more about the Buxco inhalation tower
Inhalation Tower with Allay Restraints - Mouse


Anipill group housed temperature implant
This temperature-only implant is for use in small animals, offering a simple and portable system to automatically collect temperature in socially-housed environments. 

Learn more about Anipill temperature implants
Anipill_ruler