CBRN Defense

Scientific Overview of CBRN

CBRN (chemical, biological, radiological or nuclear) research aims to identify protective or defense measures that can be applied in situations where advanced research and development of medical countermeasures are necessary.

Research conducted to characterize medical interventions for humans follow the FDA’s Animal Rule addressing efficacy using animal models for translation of disease manifestations and potential treatments.  

Researchers are often interested in physiologic parameters to detect changes in fever, heart rate, respiration, sleep and seizure activities. Wireless physiological monitoring has established its position as a technology that enables researchers to acquire data on ambulatory animal models that closely represent human scenarios; thus, providing critical physiologic data not feasible via other methods. 

Gathering data to aid in the development of defense countermeasures to preserve human life, is trusted to advanced technologies provided by DSI.

  • Implantable telemetry increases safety for personnel by providing information remotely, and limiting human to subject interactions
  • Plethysmography solutions help researchers understand potential side effects when respiratory airways airways are the focus of interest

Using DSI technologies, researchers safely collect data for a complete physiologic view of animal models and the impact to physiologic changes during these important studies. (Note: DSI markets and sells to companies that use our products to perform biological and chemical defense research. We do not sell biological or chemical products. We do not produce products that can be used to manufacture biological or chemical agents. We do not sell products that can be used to transport or deliver biological or chemical agents.)

Methods and Parameters

Physiologic data is critical to understanding disease morphology and physiologic response for the establishment of treatment regimens for chemical, biological, radiation and nuclear countermeasures.

Parameters Commonly Measured by CBRN Researchers include assessment of respiratory function.  Implantable telemetry can be combined with chamber systems to collect cardiovascular, EEG, temperature, activity and respiratory function in a single system.


CBRN articles citing DSI telemetry in Google Scholar


CBRN articles citing DSI respiratory systems Google Scholar

PhysioTel Digital large animal implants
DSI offers several different implant combinations to measure different parameters including pressure, biopotentials, temperature and activity. 

Learn more about PhysioTel Digital products.

L21 Implant

Ponemah Remote Notification
Convenient, automated alerts for subject-level and system-level conditions. Continuous physiologic monitoring should not need your undivided attention. Constantly checking data acquisition throughout the day, on weekends, or the middle of the night isn’t an efficient use of your time. Ponemah provides peace of mind by monitoring subject health and system functionality,notifying you when necessary.
Learn more about the Ponemah Remote Notification software feature
Remote Notification Email

PhysioTel large animal respiratory implant
This first-of-its-kind device, the D70-PCTR, is a versatile option for researchers with a need to monitor a pressure, biopotential, temperature, respiratory volume,  respiration rate and activity.

Learn more about the PhysioTel large animal respiratory implant

Buxco respiratory exposure systems
DSI’s Buxco Mass Dosing Chambers are used to expose multiple subjects to an aerosol or gas when general dosing can be tolerated. For precise nose-only exposures, use the Inhalation Tower system.

Learn more about Buxco inhalation and exposure systems
Mass Dosing system

Continuous glucose telemetry implant

Continuous blood glucose monitoring can be used as a marker of damage or recovery for many models of chemical or radiation exposure.

Learn more about implantable glucose telemetry
Glucose Implant

Data analysis and report generation services
DSI delivers high-quality, customized, comprehensive reports for evaluation of: hemodynamics, heart rate variability, ECG interval quantification, arrhythmia detection, seizure detection, sleep scoring, blood pressure, respiration, temperature and activity that change from study to study and subject to subject. 

Learn more about data analysis and report generation services

Pre-implantation services
The choice is yours: Surgeries performed at your location on your test subjects, or Pre-implanted animals are delivered to your location. 

Learn more about DSI's pre-implantation services 

Buxco inhalation dosing tower

For use with small animals, inhalation dosing towers ensure that simultaneous exposure of compounds or gases to the lungs of rodents is well controlled, consistent, and defined.

Learn more about the Buxco inhalation tower
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