A seizure is an episode of increased or irregular electrical activity
in the brain that can present as a single event or exhibit recurrent characteristics (epilepsy). There is currently no cure for seizure
disorders and animal models remain vital to increase our
understanding of underlying pathophysiological mechanisms
and in new treatment development.
Common Causes of Seizures
- High fever
- Traumatic Brain Injury or Head Trauma
- Brain Tumor
- Illegal or Recreational Drug Use
- Alcohol Abuse or Withdrawal
Commonly Used Species in Seizure Research
We have created this table of seizure models to provide you with more information regarding the various species, EEG placement, and applications that have been studied in seizure research.
In vivo electrophysiological recordings, mainly electroencephalograms (EEG), are invaluable in the diagnosis of seizures in preclinical and clinical settings. EEGs are highly translatable and provide information about electrical activity of animal or human brains during and in the absence of seizures. When EEGs are combined with video monitoring, this powerful multimodal approach adds validity to studies through synchronized recording of brain activity and behavior analysis for seizure confirmation and observation of therapeutic effects.
In vitro - Extracellular Field and Action Potential
In vitro - Ion Selectivity
*In Vitro solutions are available from our Harvard Bioscience sister brands Multichannel Systems and Heka Elektronik. Reach out to us to learn more about how to incorporate these solutions into your current research set-up.
Google Scholar Indexes 329 Publications Citing DSI, Seizure and EEG
Common behavioral responses observed during a seizure include freezing or shift of attention, loss of consciousness, and violent or rhythmic muscle contractions. Researchers use many different behavioral assays to study changes during seizure activity as well as the effects of repetitive seizures in epileptic disorders. Video tracking and monitoring can be combined with EEG tracing to provide the most accurate picture of seizure activity in animal models.
Working and Spatial Memory
Nest-building and Burrowing Behavior
*Behavioral solutions are available from our Harvard Bioscience sister brands Panlab and Coulbourn Instruments. Reach out to us to learn more about how to incorporate these solutions into your current research set-up.
Google Scholar Indexes 230 Publications Citing DSI, Seizure and Video
Google Scholar Indexes 498 Publications Citing Panlab and Seizure
Google Scholar Indexes 711 Publications Citing Coulbourn and Seizure
Seizures are known to cause autonomic dysfunction, contributing to possible conduction disturbances within the heart. This can lead to a higher risk of sudden unexpected death in epilepsy through changes in heart rate variability, increases in QT interval, and arrhythmias that can occur before, during, or after a seizure.
Mean Arterial Pressure
Pulmonary Blood Pressure
Google Scholar Indexes 152 Publications Citing DSI, Seizure and Cardiovascular
Complications in respiratory function are commonly observed prior to and during seizure events. These include changes in respiratory rate, respiratory pausing, hypercapnia, hypoxemia, and aspirations. While most seizures don't lead to respiratory complications, SUDEP (sudden unexpected death in epilepsy) is linked to low oxygen levels that occur due to seizure activity. Tonic-clonic, uncontrolled and night time seizures increases a persons risk of SUDEP. Researchers will commonly combine respiratory monitoring with electrophysiology in their seizure studies to improve acute treatment outcomes.
Inspiratory and Expiratory Duration
Peak Airflow Rates
Specific Airway Resistance
Volume and Functional Residual Capacity
Respiratory Muscle Function
Google Scholar Indexes 90 Publications Citing Buxco and Seizure
Hyperthermia has been shown to affect temperature sensitive ion channels, increasing excitability within the brain which can trigger seizure activity. The most common causes of seizures associated with increases in core body temperature are febrile seizures and exposure to high temperature conditions, such as heat stroke.
Core Body Temperature
Google Scholar Indexes 355 Publications Citing DSI, Seizure and Temperature
Both hyperglycemia and hypoglycemia can trigger seizures, particularly in diabetic patients with uncontrolled glucose levels caused by insulin errors, illness or altered metabolic states. Chronic glucose monitoring in seizure models can provide a better understanding of how alterations in glucose metabolism affects the electrical activity in the brain.
Google Scholar Indexes 154 Publications Citing DSI, Seizure and Glucose