Peer-Reviewed Infectious Disease Publications
Mycobacterium tuberculosis Sulfolipid-1 Activates Nociceptive Neurons and Induces Cough
Ruhl, C. R., Pasko, B. L., Khan, H. S., Kindt, L. M., Stamm, C. E., Franco, L. H., … Shiloh, M. U. (2020, March 5).
Study looking at the mechanisms of cough reflex in M. tuberculosis guinea pig models. Cough and respiratory data were collected and analyzed using unrestrained whole-body plethysmography and software (Buxco FinePointe)
Development, Characterization, and Standardization of a Nose-Only Inhalation Exposure System for Exposure of Rabbits to Small-Particle Aerosols Containing Francisella tularensis.
O’Malley, K. J., Bowling, J. D., Barry, E. M., Hazlett, K. R. O., & Reed, D. S. (2019, August 1).
Infectious disease, Francisella tularensis, exposed to rabbits to develop standardized model and decrease variability in future studies. Respiratory function data was collected (Buxco XA or FinePointe software) in real time during the aerosol exposures, while animals were unrestrained in whole-body plethysmography chambers (Buxco).
Characterization of deposition patterns of inhaled aerosol particle size and virulence in non-human primates. Imaging was used to quantify deposition patters and allow the same animals to be exposed to different particle sizes. During each particle size challenge, all subject respiratory function was monitored using respiratory induction plethysmography (DSI JET).
Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome
Leist, S. R., & Cockrell, A. S. (2019, December 28). Retrieved March 22, 2020, from
Evaluating the use of genetically modified mouse models in Middle East respiratory syndrome (MERS) coronavirus vaccine and treatment studies. Researchers exposed mice intranasally to MERS virus and used unrestrained whole-body plethysmography (Buxco) to monitor respiratory function as additional metric for morbidity.
An aerosol challenge model of Mycobacterium tuberculosis in Mauritian cynomolgus macaques
Sharpe, S. A., White, A. D., Sibley, L., Gleeson, F., Hall, G. A., Basaraba, R. J., … Dennis, M. J. (2017). . Plos One, 12(3).
Pilot study using a less genetically diverse non-human primate to look for more reproducible responses to M. tuberculosis infection. Head-out plethysmography chambers (Buxco) were used during intranasal exposure to measure respired volume.
Immunogenicity and Efficacy of a Measles Virus-Vectored Chikungunya Vaccine in Nonhuman Primates
Rossi, L, S., E, J., Wang, Eryu, Azar, … C, S. (2019, May 3).
A new measles virus-vectored chikungunya vaccine and challenge study was evaluated in non-human primates. Implantable telemetry (DSI) was used to monitor body temperature and activity.
Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri)
Sanada, T., Yasui, F., Honda, T., Kayesh, M. E. H., Takano, J.-ichiro, Shiogama, Y., Kohara, M. (2019, January 19).
Avian influenza viruses studied in Northern tree shrews as suitable animal model for avian flu research. Researchers monitored fever and activity with implantable telemetry (DSI).\
Using Telemetry Data to Refine Endpoints for New Zealand White Rabbits Challenged with Bacillus anthracis
Dawson, G, D., Bower, Kristin, Burnette, N, C., … Angelo. (2017, November 1).
Study looking at early indicators of death in New Zealand white rabbits exposed to Bacillus anthracis (anthrax) to improve animal welfare. Animals were challenged with anthrax using inhalation or subcutaneous techniques. Implantable telemetry (DSI) was used to monitor sudden increases of body temperature.
Electrocardiography Abnormalities in Macaques after Infection with Encephalitic Alphaviruses
Ma, Henry, Lundy, O’Malley, J., K., B., W., … Reed. (2019, November 16).
Non-human primates were exposed to Encephalitis Alphaviruses to evaluate electrocardiogram (ECG) changes throughout disease progression. A respiratory inductance plethysmography system was used during exposure to monitor respiratory function and implantable telemetry (DSI) collected ECG data during the course of the study.
Comparative study characterizing human models of equine encephalitis viruses in exposed cynomolgus macaques. Respiratory induction plethysmography used during exposure and software (Ponemah) collected respiratory function data. Implantable telemetry (DSI) was used to monitor electrocardiogram and temperature data throughout study.