The collection of functional cardiovascular, neurological and respiratory endpoints, are most commonly achieved using Jacketed External Telemetry (JET™), Implantable Telemetry, or Hardwired Instrumentation.
In 2014, DSI released the PhysioTel Digital M series telemetry implants. These devices were designed for toxicologists seeking lower cost implants for use in studies with shorter duration and/or more test subjects. Importantly, researchers have found no histopathology issues following study completion.
Until recently, many toxicologists believed that the surgical implantation of sensors and telemetry devices would cause pathology that would confound the toxicologic pathology endpoints being evaluated in the study. However, consultation with experienced pathologists participating in the HESI Cardiac Safety Technical Committee has largely removed this concern. Pathologists are confident that they can easily distinguish pathology related to implanted foreign bodies from the pathological effects of experimental drugs.
In 2014, DSI also acquired Buxco Respiratory Systems, increasing our breadth of respiratory solutions for toxicology researchers, including inhalation towers, smoke generators, and whole body plethysmography chambers.
Physiologic Parameters Available for DSI Toxicology Solutions
|Telemetry ||Hardwired |
|Implantable ||External |
|Blood Pressure ||x ||x ||x |
|ECG ||x ||x ||x |
|Other Biopotentials (EMG, EEG, etc.) ||x || ||x |
|Ventricular Pressure ||x || ||x |
|Pulse Wave Velocity ||x || ||x |
|Blood Flow ||x || ||x |
|Heart Rate Variability ||x ||x ||x |
|PV Loop || || ||x |
|Action Potentials || || ||x |
|Isolated Heart/Tissue || || ||x |
|Respiratory Rate ||x ||x ||x |
|Tidal Volume ||x ||x ||x |
|Minute Volume ||x ||x ||x |
Functional endpoints are collected from conscious, freely moving animals that have a small device implanted into them that is capable of monitoring ECG, Blood Pressure, Temperature, and Activity data and transmitting data to an acquisition and analysis computer system.
Jacketed External Telemetry
JET is an externally-worn Bluetooth® enabled telemetry device designed for large animal toxicology studies. JET can be used to monitor ECG, blood pressure, respiration, temperature and activity.
Short durations of functional endpoints are collected from chemically or physically restrained animals that are connected to external devices capable of monitoring ECG and recording directly into an acquisition and analysis computer system.
DSI Respiratory Solutions
Please see the respiratory solutions page for detailed information on DSI's respiratory offering.