PFT Controller, Calibrator, and Chambers

Pulmonary Function Test

Similar to spirometry in cooperative humans, the Buxco® pulmonary function testing system provides comprehensive PFT data for pre-clinical applications. For the functional residual capacity (FRC) test, subjects must be spontaneously-breathing. For other tests, subjects may be ventilated (ventilator included) or spontaneously-breathing. Subjects are anesthetized and the tests are automated.

Features

• Most comprehensive assessment of the lung
• Complete a series of tests in just minutes
• View results immediately, use overlays to compare repeated tests
• Ideal for chronic obstructive pulmonary disease (COPD) studies
• Determine FRC and other lung capacities
• Software reports forced expiratory volume (FEV), forced expiratory flow (FEF) and many other values
• Direct measurement of pulmonary mechanics—lung resistance and dynamic compliance
• Reports produce group average of P-V loops and F-V loops

Available for: Mice, Rats, Rabbits, Ferrets, Guinea Pigs, and NHP. Additional species or custom chambers may be available upon request.

Available tests

  • Boyle’s Law FRC
  • Fast Flow Volume 
  • Quasistatic Pressure Volume 
  • Buxco Resistance and Compliance analysis is also available.



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Publications

Marcos V, Zhou-Suckow Z, Yildirim A, Bohla A, Hector A, Vitkov L, Krautgartner W, Stoiber W, Griese M, Eickelberg O, Mall M, Hartl D. “Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction.” Mediators of Inflammation. 2015.

Radhakrishnan S, Palaniyandi S, Mueller G, Miklos S, Hager M, Spacenko E, Karlsson F, Huber E, Kittan N, Hildebrandt G. “Preventive Azithromycin Treatment Reduces Noninfectious Lung Injury and Acute Graft-versus-Host Disease in a Murine Model of Allogeneic Hematopoietic Cell Transplantation.” Biology of Blood and Marrow Transplantation. 2015;21:30-38.

Kamiide Y, Inomata N, Furuya M, Yada T. “Ghrelin ameliorates catabolic conditions and respiratory dysfunction in a chronic obstructive pulmonary disease model of chronic cigarette smoke-exposed rats.” European Journal of Pharmacology. 2015;755:88-94.

Wan Y, Huang Z, Jing K, Li J, Wang Y, Xu C, Chen J, Zheng Y. “Azithromycin Attenuates Pulmonary Inflammation and Emphysema in Smoking-Induced COPD Model in Rats.” Respiratory Care. 2015;60(1):128-134.

1620
Pulmonary Function Testing articles citing DSI in Google Scholar