Social Interaction

Study of social behaviors in rodents is used to glean insight into human disorders that coincide with social dysfunction, such as autism and schizophrenia. Protocols such as the three-chamber sociability test provide screening of social preference, recognition, and memory. Other test designs may be employed to explore aspects of social dominance and aggression. Also of interest are protocols such as observational fear conditioning that capture empathy-like and pro-social responses.

Social Interaction

Common Applications

  • Autism Spectrum Disorders
  • Fragile X Syndrome
  • Schizophrenia
  • Aggression
  • Social Phobia
  • Anxiety Disorders
  • Depression
  • Phenotyping

Combining your Behavioral Assessments with Other In Vivo Techniques?

Ask us about our tether-compatible arenas and digital interface options. Whether it is integration of electrophysiology, fiber photometry, telemetry, optogenetic stimulation, or video recording—we offer a range of behavioral solutions designed with multidisciplinary approaches in mind.

Social Box


Recent References

1. Nishiguchi T, Iwata M, Kajitani N, Miura A. et al. Stress increases blood beta-hydroxybutyrate levels and prefrontal cortex NLRP3 activity jointly in a rodent model. Neuropsychopharmacol Rep. 2021 Jun;41(2):159-167.

2. Mukai S, Nakada S, Kamada H. et al. Differential sensitivity to detect prosocial effects of 3,4-methylenedioxymethamphetamine (MDMA) in different social approach paradigms in mice. Neuropsychopharmacol Rep. 2020 Sep;40(3):297-301.

3. Luo CW, Deng XY, Cheng JL. et al. Altered anxiety and social behaviors in a mouse model of Fragile X syndrome treated with hyperbaric oxygen therapy. J Clin Neurosci. 2020 Mar;73:245-251.

4. Sancho-Balsells A, Brito V, Fernández B. et al. Lack of Helios During Neural Development Induces Adult Schizophrenia-Like Behaviors Associated With Aberrant Levels of the TRIF-Recruiter Protein WDFY1. Front Cell Neurosci. 2020 May 14;14:93.

5. Boillat M, Hammoudi PM, Dogga SK. et al. Neuroinflammation-Associated Aspecific Manipulation of Mouse Predator Fear by Toxoplasma gondii. Cell Rep. 2020 Jan 14;30(2):320-334.e6.

6. Nakatake Y, Furuie H, Yamada M. et al. The effects of emotional stress are not identical to those of physical stress in mouse model of social defeat stress. Neurosci Res. 2020 Sep;158:56-63.

7. Alegre-Zurano L, Martín-Sánchez A, Valverde O. Behavioural and molecular effects of cannabidiolic acid in mice. Life Sci. 2020 Oct 15;259:118271.

8. Nagai M, Nagai H, Numa C, Furuyashiki T. Stress-induced sleep-like inactivity modulates stress susceptibility in mice. Sci Rep. 2020;10(1):19800.

9. Ano Y, Kitaoka S, Ohya R. et al. Hop Bitter Acids Increase Hippocampal Dopaminergic Activity in a Mouse Model of Social Defeat Stress. Int J Mol Sci. 2020;21(24):9612.

10. Nakatake Y, Furuie H, Ukezono M. et al. Indirect exposure to socially defeated conspecifics using recorded video activates the HPA axis and reduces reward sensitivity in mice. Sci Rep. 2020 Oct 9;10(1):16881.