Support Center

Combined Research Techniques

Integrate study techniques and tools to unlock new opportunities in your research 



DSI solutions are used in combination with many other technologies for various research applications in both small and large animal models. The benefits of holistic research includes a greater chance of study approval and funding, a decrease in the number of animals used, the ability to identify physiological changes from multiple organ systems, and overall better science.

Synchronize implantable telemetry with hardwired data by using DSI's products listed below.
Implantable Telemetry
Signal Conditioners and Amplifiers
Signal Interface
 

Below are examples of combined techniques researchers have used. If you would like to discuss your application or learn about additional combination studies, click the schedule a free call button below. 


 




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WHOLE BODY PLETHYSMOGRAPHY AND TELEMETRY


Whole body plethysmography (WBP) and telemetry remain the recommended techniques for obtaining physiological assessments in small animals. Combining respiratory WBP with cardiovascular or CNS telemetry endpoints provides researchers looking at holistic effects and multi organ interactions with powerful data from one subject. 




COMBINATION BENEFITS
  • Obtain both respiratory and cardiovascular endpoints
  • Longitudinal study approaches
  • Understand the interactions between organ systems
  • Utilize the same Ponemah software platform
  
FUNCTIONS AND PARAMETERS
  • Heart Rate, Blood Pressure, ECG
  • EEG, EMG, Sleep
  • Respiratory Rates, Volumes, Flows
  • Resistance
  
APPLICATIONS
  • Sleep apnea
  • Earlier drug development safety assessments
  • Circadian Rhythm
  • Cardiorespiratory interactions 
  • Heart failure
  • Spinal injury
  • Anxiety
  • Recreational and addictive drug effects
  • Epilepsy  
 
 
Opioid addiction webinar highlights combined use of EEG telemetry and plethysmography
 
 

WHOLE BODY PLETHYSMOGRAPHY AND TETHERED SYSTEMS

Specially designed respiratory whole body plethysmographs (WBP) offer the flexibility to integrate tethered animal models; allowing the ability to combine technologies or have access to the animal while in the chamber.

  • Optogenetics - Neural control of breathing
  • Electrical Commutator - Collect hardwired biopotential (EEG, EMG, EOG) signals simultaneously
  • Fluid Swivel - Administer compound, manage pain, draw blood, or create an injury model

Suitable for mouse, rat, and guinea pig animal models



WBP Tower Rat with Optogenetics and extension ring
Optogenetics

WBP Rat Tower with Swivel
Fluid Swivel


WBP Tower Rat with commutator and extension ring
Electrical Commutator

COMBINATION BENEFITS
  • Obtain additional physiological data to understand multi-organ interaction
  • Stimulate or record using tethered technology
  • Vascular access for delivery or sampling
FUNCTIONS AND PARAMETERS
  • Heart Rate, Blood Pressure, ECG, EOG
  • EEG, EMG, Sleep
  • Respiratory Rates, Volumes, Flows
  • Resistance
APPLICATIONS
  • Sleep apnea
  • Respiratory depression
  • Pain management
  • Recreational and addictive drug effects
  • Cardiorespiratory stimulation
  • Hypoxia/hypercapnia effects
  • Anxiety
  • Epilepsy/Seizures
  • Blood sampling / drug administration

METABOLISM AND TELEMETRY

The link between metabolism and the cardiovascular system has been getting more attention in the 21st century with the increased rate of obesity and type two diabetes, and their link to cardiovascular disease. Researchers are using animal models to assess early, mid and late stage metabolic diseases, as well as metabolic circadian rhythm and hibernation trends. By adding hemodynamic parameters with metabolic and hibernation studies, researchers are able to assess blood pressure, ECG, blood glucose, temperature and activity in a single animal. The combination of these applications also helps to separate excitement responses due to room entry or food offering, and actual changes in blood glucose.




HD S11 and XG

Cardiovascular and Glucose Telemetry from one Animal

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Telemetry with Calorimetry 

COMBINATION BENEFITS
  • Real-time cardiovascular, temperature and/or glucose data
  • A better understanding of clusters of conditions and related activity that are often associated with metabolic diseases, hypertension and diabetes. 
  • Decreased handling in home cage environments, while obtaining high quality physiological data, that minimizes animal stress and increased translation
  • A more comprehensive, holistic picture of whole animal cardiovascular and metabolic physiology
FUNCTIONS AND PARAMETERS
  • Heart Rate, Blood Pressure, ECG
  • Continuous Glucose Monitoring
  • EEG, EMG, Sleep
  • Respiratory Rates
  • Body Temperature
  • VO2 Consumption, VCO2 Production, Respiratory Exchange Ratio and Energy Expenditure
  • Food and Drink Consumption
  • Activity
APPLICATIONS