COPD



COPD (chronic obstructive pulmonary disease) is a progressive disease that makes it hard to breathe.  The primary contributor to COPD is cigarette smoke.  COPD is the third leading cause of death in the U.S., and there is no cure.

The two primary conditions are:

  • Emphysema- Damage to the walls between air sacs, causing destruction of the lungs over time.
  • Chronic bronchitis- inflammation and thickening of airway lining, mucus development, and chronic cough.

Rodents are the typical species used when studying COPD. Recent publications suggest that cigarette smoke exposure to animals, using a smoke generating device, is the best approximation to human COPD. Other approaches include long-term lipopolysaccharide (LPS) exposure and the use of genetically modified models.

Primary endpoints of interest include static and dynamic compliance and lung volumes. 

DSI solutions are helping researchers learn more about how to treat COPD.

546
COPD articles citing DSI in Google Scholar



Smoke Generator – Completely automated and capable of burning up to 300 cigarettes, the smoke generator captures direct and indirect smoke and delivers it to an exposure apparatus including chambers, towers, or individual exposure tubes.

Learn more about the Buxco Smoke Generator from DSI. 
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FPRC - FinePointe resistance and compliance hardware helps researchers measure an animal’s airflow and lung pressure. This anesthetized approach allows for direct measurement of an animal’s response to a bronchoconstrictor either using an aerosol or I.V.

Learn more about FinePointe resistance and compliance hardware.

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PFT - The pulmonary function testing system allow for a comprehensive assessment of the lungs.  All lung volumes and spirometry equivalent test results are completed in a matter of minutes; allowing for high throughput and quicker results.

Learn more about pulmonary function testing products from DSI.

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FinePointe Software – FinePointe software is powerful and easy-to-use for collecting, analyzing, and reporting life science data. Fully network-enabled, the smart design minimizes required user interaction while wizards walk users through necessary procedures.

Learn more about Buxco FinePointe software from DSI.

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References

Bosnjak B, Tilp C, Tomsic C, Dekan G, Pieper M, Erb K, Epstein M. “Tiotropium bromide inhibits relapsing allergic asthma in BALB/c mice.” Pulmonary Pharmacology and Therapeutics. 2014;27:44-51.

Khaitov M, Shilovskiy I, Nikonova A, Shershakova N, Kamyshnikov O, Babakhin A, Zverev V, Johnston S, Khaitov R. “Small interfering RNAs targeted to interleukin-4 and respiratory syncytial virus reduce airway inflammation in a mouse model of virus-induced asthma exacerbation.” Human Gene Therapy. 2014;25:642-650.

Haapakoski R, Karisola P, Fyhrquist N, Savinko T, Wolff H, Turjanmaa K, Palosuo T, Reunala T, Lauerma A, Alenius H. “Intradermal cytosine-phosphate-guanosine treatment reduces lung inflammation but induces IFN-gamma-mediated airway hyperreactivity in a murine model of natural rubber latex allergy.” American journal of respiratory cellular and molecular biology. 2011;44:639-647.