Operant Conditioning





Operant conditioning is a form of associative learning through which animals take voluntary action to achieve a desired outcome. Often performed in “Skinner boxes”, operant paradigms span the gamut of applications, from study of diverse cognitive processes and addiction, to emotional state. Compact and fully modular chamber solutions are available to support a range of experimental needs and implementation.

OC






Common Applications

  • Schizophrenia
  • Mood Disorders
  • Dementias
  • Aging
  • Brain Injuries
  • Addiction

  •  Stroke/Ischemia
  • Alzheimer's Disease
  • Neurodegenerative Diseases
  • Attention Deficit Disorders
  • Safety Pharmacology
  • Gambling/Compulsive Disorders





Combining Operant Behavior with External Techniques?

The Coulbourn Habitest system is designed with multidiscliplinary approach in mind. Whether it is integration of electrophysiology, fiber photometry, telemetry, optogenetic stimulation, or video recording—the Habitest system is ready to support your success with a range of features and options.


PL and MCS



Benefits of the Habitest System: 
  • Fast, 1 ms time resolution for timestamping with neural events
  • Floor grounding relays to minimize electrical noise during shock protocols
    Extended opening feeders for head-mounted animals.
  • Camera mounting solutions compatible with tethered animals
  • Digital interface modules for synchronization to 3rd party data acquisition systems
  • Combination with DSI telemetry, MCS electrophysiology, Panlab video recording and other Harvard Bioscience solutions


 





Recent References

1. Wiley JL, Barrus DG, Farquhar CE, Lefever TW, Gamage TF. Sex, species and age: Effects of rodent demographics on the pharmacology of ∆9-tetrahydrocanabinol. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 2;106:110064.

2. Dela Peña I, Shen G, Shi WX. Droxidopa alters dopamine neuron and prefrontal cortex activity and improves attention-deficit/hyperactivity disorder-like behaviors in rats. Eur J Pharmacol. 2021 Feb 5;892:173826.

3. Ball KT, Arnsberger BJ, McDonald RM. Sex-dependent effects of chronic stress on reinstatement of palatable food seeking and involvement of dopamine D1-like receptors. Behav Brain Res. 2021 Jan 1;396:112921.

4. Chisholm A, Rizzo D, Fortin É. et al. Assessing the Role of Corticothalamic and Thalamo-Accumbens Projections in the Augmentation of Heroin Seeking in Chronically Food-Restricted Rats. J Neurosci. 2021 Jan 13;41(2):354-365.

5. Aparicio CF, Malonson M, Hensley J. Analyzing the magnitude effect in spontaneously hypertensive (SHR) and wistar Kyoto (WKY) rats. Behav Processes. 2020 Dec;181:104258.

6. Chakraborty S, Tripathi SJ, Raju TR, Shankaranarayana Rao BS. Brain stimulation rewarding experience attenuates neonatal clomipramine-induced adulthood anxiety by reversal of pathological changes in the amygdala. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Dec 20;103:110000.

7. Hauser SR, Waeiss RA, Molosh AI, Deehan GA Jr, Bell RL, McBride WJ, Rodd ZA. Atrial natriuretic peptide (ANP): A novel mechanism for reducing ethanol consumption and seeking behaviors in female alcohol preferring (P) rats. Peptides. 2020 Dec;134:170403.

8. Westbrook SR, Gulley JM. Effects of the GluN2B antagonist, Ro 25-6981, on extinction consolidation following adolescent- or adult-onset methamphetamine self-administration in male and female rats. Behav Pharmacol. 2020 Dec;31(8):748-758.

9. Higginbotham JA, Wang R, Richardson BD, Shiina H, Tan SM, Presker MA, Rossi DJ, Fuchs RA. CB1 receptor signaling modulates amygdalar plasticity during context-cocaine memory reconsolidation to promote subsequent cocaine seeking. J Neurosci. 2020 Nov 30:JN-RM-1390-20.

10. Padovani L, Tesoriero C, Vyssotski A, Bentivoglio M, Chiamulera C. Hippocampal gamma oscillations by sucrose instrumental memory retrieval in rats across sleep/wake cycle. Neurosci Lett. 2020 Sep 25;736:135255.