-
ECG
Johansson, C., Thoren, P. “The effects of triiodothyronine (T3) on heart rate, temperature and ECG measured with telemetry in freely moving mice.” Acta Physiol Scand. 1997 Jun; 160(2): 133-8.
London, B., “Cardiac arrhythmias: From (transgenic) mice to men.” J Cardiovascular Electrophysiology. 2001 Sep; 12(9):1089-1091.
Petric, Clasen, van Weßel, et al., “In vivo electrophysiological characterization of TASK-1 deficient mice.” Cellular Physiology and Biochemistry. 2012.
HR
Spani, D., Arras, M., Konig, B., Rulicke, T., “Higher heart rate of laboratory mice housed individually vs in pairs”. Laboratory Animals. 2003; 37: 54-62.
Costoli, T., Bartolomucci, A., Graiani, G., Stilli, D., Laviola, G., Sgoifo, A., “Effects of chronic psychosocial stress on cardiac autonomic responsiveness and myocardial structure in mice”. Am J Physiol Heart Circ Physiol. 2004 Feb; 286(6): H2133-40.
Kramer, Klaas, et al. “Effect of conditioning on the increase of heart rate and body temperature provoked by handling in the mouse.” ATLA, Alternatives to laboratory animals. 2004; 32: 177-181.
-
ECG
Sgoifo, A., et al., “Electrode positioning for reliable telemetry ECG recordings during social stress in unrestrained rats.” Physiology and Behavior. 1996 Mar; 60(6):1397-1401.
Sgoifo, A., Pozzato, C., Meerlo, P., Costoli, T., Manghi, M., Stilli, d., Olivetti, G., Musso, E., “Intermittent Exposure to Social Defeat and Open-field Test in Rats: Acute and Long-term Effects on ECG, Body Temperature and Physical Activity”. Stress. 2002; 5(1): 23-35.
Rey, M., Weber, E.W., Hess, P.D., “Simultaneous Pulmnary and Systemic Blood Pressure and ECG Interval Measurement in Conscious, Freely Moving Rats.” Journal of the American Assoc for Laboratory Animal Science. 2012 March; 51(2): 231-8.
HR
Mailliet, F., Galloux, P., Paisson, D., “Comparative effects of melatonin, zolpidem and diazepam on sleep, body temperature, blood pressure and heart rate measured by radiotelemetry in Wistar rats”. Psychopharmacology. 2001 May; 156: 417-26.
Azar, T.A., Sharp, J.L., Lawson, D.M., “Effect of Housing Rats in Dim Light or Long Nights on Heart Rate”. Journal of the American Assoc for Laboratory Animal Science. 2008 July; 47(4): 25-34.
Blood Pressure
Kasanen, I. H. E., et al. "Comparison of ear tattoo, ear notching and microtattoo in rats undergoing cardiovascular telemetry." Laboratory Animals45.3 (2011): 154-159.
Panneton, W. Michael, et al. "Activation of brainstem neurons by underwater diving in the rat." Frontiers in physiology 3 (2012).
Daneshvar, Hamid, et al. "Cardiovascular Assessment in Radiotelemetry-Implanted Pregnant Rats." Journal of Investigative Surgery 24.1 (2011): 35-43.
Segreti, Jason A., et al. "Simultaneous measurement of arterial and left ventricular pressure in conscious, freely moving rats by telemetry." Journal of Pharmacological and Toxicological Methods 64.1 (2011): e30.
Lujan, Heidi L., et al. "Ventricular function during exercise in mice and rats."American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 302.1 (2012): R68-R74.
Hildreth, Cara M., Ann K. Goodchild, and Jacqueline K. Phillips. "Insight into Autonomic Nervous System Control of Heart Rate in the Rat Using Analysis of Heart Rate Variability and Baroreflex Sensitivity." Stimulation and Inhibition of Neurons. Humana Press, 2013. 203-223.
Snelder, N., et al. "PKPD modeling of the interrelationship between mean arterial blood pressure, cardiac output and total peripheral resistance in conscious rats." British Journal of Pharmacology (2013).
Samuelsson, Anne-Maj, et al. "Evidence for sympathetic origins of hypertension in juvenile offspring of obese rats." Hypertension 55.1 (2010): 76-82.
Kroehle, John, et al. "A novel biomaterial catheter for improved cardiac contractility measurement in freely moving animals." Journal of Pharmacological and Toxicological Methods 66.2 (2012): 190.
-
Gerber, P., Schnell, C.R., Anzenberger, G., “Cardiovascular Parameters Telemetrically Measured During Pregnancy, Parturition, and Lactation in a Common Marmoset (Callithrix jacchus)”. Contemp top Lab Sci. 2000 Sept; 39(5): 14-7.
Kitayama, Tetsuya, et al. "Evaluation of effects on cardiac contractility in conscious common marmosets using telemetry." Journal of Pharmacological and Toxicological Methods 66.2 (2012): 195-196.
-
Akita, M., Kuwahara, M., Nishibata, R., Mikami, H., Tsubone, H., “The Daily Pattern of Heart Rate, Body Temperature, Locomotor Activity, and Autonomic Nervous Activity in Congenitally Bronchial-Hypersensitive (BHS) and Brochial-Hyposensitive (BHR) Guinea Pigs”. Experimental Animal. 2004 April; 53(2): 121-127.
Provan, G., Stanton, A., Sutton, A., Rankin-Burkart, A., Laycock, S.K., “Development of a surgical approach for telemetering guinea pigs as a model for screening QT interval effects”. Journal of Pharmacological and Toxicological Methods. 2005 Sep; 52(2): 223-8.
Hess, P.,Rey, M., Wanner, D., Steiner, B., Clozel, M., “Measurements of blood pressure and electrocardiogram in conscious freely moving guineapigs: a model for screening QT interval prolongation effects.” Laboratory Animals. 2007 Jan; 41:470-480.
-
Chu, Kit-Man, et al. "Olvanil: A non-pungent TRPV1 activator has anti-emetic properties in the ferret." Neuropharmacology 58.2 (2010): 383-391.
-
Weaver, Lara A., et al. "A model for clinical evaluation of perioperative analgesia in rabbits (Oryctolagus cuniculus)." Journal of the American Association for Laboratory Animal Science: JAALAS 49.6 (2010): 845.
Ronisz, Alicja, Marion Delcroix, and Rozenn Quarck. "Measurement of right ventricular pressure by telemetry in conscious moving rabbits." Laboratory Animals (2013).
Tate, Mallory K., et al. "Telemetric left ventricular monitoring using wireless telemetry in the rabbit model." BMC research notes 4.1 (2011): 320.
-
Electrocardiogram (ECG)
Tracy A. Henriques, Thomas W. Beck, Christopher L. Douglas, Hilton M. Jones, John J. Kremer, Paul J. Kruzich, R. Dustan Sarazan, “Left thoracotomy surgical approach for chronic instrumentation in dogs and monkeys providing high-quality electrocardiogram signals". Journal of Pharmacological and Toxicological Methods. 2010 Sept; Vol 62 (2): 136-142.
Chui, Ray W., Katayoun Derakhchan, and Hugo M. Vargas. "Comprehensive analysis of cardiac arrhythmias in telemetered cynomolgus monkeys over a 6 month period." Journal of Pharmacological and Toxicological Methods (2012).
Authier, S., et al. "Evaluation of a novel ECG lead placement method in telemetered freely moving cynomolgus monkeys: Assessment of an intravascular biopotential lead." Journal of Pharmacological and Toxicological Methods 64.2 (2011): 145-150.
Hoffmann, Michael, et al. "A novel telemetry device for comprehensive assessment of cardiovascular function in conscious dogs." Journal of Pharmacological and Toxicological Methods 64.1 (2011): e48.
Gates, Sotereos C., et al. "Understanding the prevalence of inherent cardiac arrhythmias in the beagle dog in the assessment of drug induced changes in the ECG." Journal of Pharmacological and Toxicological Methods 64.1 (2011): e40.
Baird, Theodore J. "Influence of the local laboratory environment and selection of telemetry application on quantitative ECG sensitivity." Journal of Pharmacological and Toxicological Methods 64.1 (2011): e42-e43.
Cross, C., et al. "Detecting drug-induced prolongation of the QRS complex: New insights for cardiac safety assessment." Toxicology and applied pharmacology (2012).
Tondato, Fernando, et al. "Effects on arrhythmogenesis and arrhythmic threshold of injection of autologous fibroblasts into myocardial infarcts in adult pigs." Journal of Cardiovascular Translational Research 5.3 (2012): 337-344.
Czerski, Albert, et al. "Myoelectric activity of the muscular layer of the abdominal aorta in pigs in vivo." Acta Veterinaria Brno 81.3 (2013): 281-286.
Left Ventricular Pressure (LVP)
K. Norton, G. Iacono, M. Vezina, Assessment of the pharmacological effects of inotropic drugs on left ventricular pressure and contractility: An evaluation of the QA interval as an indirect indictator of cardiac inotropism”. Journal of Pharmacological and Toxicological Methods. 2009 Sept; Vol 60(2): 193-197.
R. Dustan Sarazan, John P. Kroehle, Bradley W. Main. “Left ventricular pressure, contractility and dP/dtmax in nonclinical drug safety assessment studies.” Journal of Pharmacological and Toxicological Methods. 2012 Oct; Vol 66(2): 71-78.
Sivarajah, A., et al. "Cardiovascular safety assessments in the conscious telemetered dog: Utilisation of super-intervals to enhance statistical power." Journal of Pharmacological and Toxicological Methods 62.1 (2010): 12-19.
Cavero, Icilio. "2011 Annual Meeting of the Safety Pharmacology Society: an overview." Expert Opinion on Drug Safety 11.2 (2012): 341-353
Sarazan, R.D. "Cardiovascular pressure measurement in safety assessment studies: Technology requirements and potential errors." Journal of Pharmacological and Toxicological Methods. http://dx.doi.org/10.1016/j.vascn.2014.06.003
Blood Pressure (BP)
Mitchell, Andrea Z., et al. "Sensitivity of two noninvasive blood pressure measurement techniques compared to telemetry in cynomolgus monkeys and beagle dogs." Journal of Pharmacological and Toxicological Methods 62.1 (2010): 54-63.
McCormick, Daniel, et al. "Frequency response of implantable blood pressure telemetry systems." Clinical and Experimental Pharmacology and Physiology 37.8 (2010): 862-869.
YANG, Hai-ying, et al. "Implantable dual pressure catheter PhysioTel telemetry in beagle dogs: its surgical operation procedures and application in safety pharmacology." Military Medical Sciences 6 (2011): 020.
Wang, Xiuqing, and Zhongjie Sun. "RNAi silencing of brain klotho potentiates cold-induced elevation of blood pressure via the endothelin pathway." Physiological genomics 41.2 (2010): 120-126.
Heath, B. M., et al. "Translation of flecainide-and mexiletine-induced cardiac sodium channel inhibition and ventricular conduction slowing from nonclinical models to clinical." Journal of Pharmacological and Toxicological Methods 63.3 (2011): 258-268.
-
McMahon, C., Mitchell, A.Z., Klein, J.L., Jenkins, A.C., Sarazan, R.D., “Evaluation of blood pressure measurement using a miniature blood pressure transmitter with jacketed external telemetry in cynomolgus monkeys”. Journal of Pharmacological and Toxicological Methods. 2010; 62 (2): 127-35.
Chui, R.W., Fosdick, A., Conner, R., Jiang, J., Bruenner, B.A., Vargas, H.M., “Assessment of two external telemetry systems (PhysioJacket™ and JET™) in beagle dogs with telemetry implants”. Journal of Pharmacological and Toxicological Methods. 2009; 60 (1): 58-68.
-
Blood Pressure
Indik JH, Donnerstein RL, Berg RA, Hilwig RW, Berg MD, Kern KB. “Ventricular fibrillation frequency characteristics are altered in acute myocardial infarction.” Crit Care Med. 2007 Apr;35(4):1133-8.
Hughes RO, Walker JK, Cubbage JW, Fobian YM, Rogier DJ, Heasley SE, Blevis-Bal RM, Benson AG, Owen DR, Jacobsen EJ, Freskos JN, Molyneaux JM, Brown DL, Stallings WC, Acker BA, Maddux TM, Tollefson MB, Williams JM, Moon JB, Mischke BV, Rumsey JM, Zheng Y, Macinnes A, Bond BR, Yu Y. “Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.” Bioorg Med Chem Lett. 2009 Aug 1;19(15):4092-6.
Mondritzki T, Kolkhof P, Sabbah HN, Gheorghiade M, Fürstner C, Schmeck C, Siedentop H, Schaefer S, Truebel H. “Differentiation of arginine vasopressin antagonistic effects by selective V2 versus dual V2/V1a receptor blockade in a preclinical heart failure model.” Am J Ther. 2011 Jan;18(1):31-7.
Mooney L, Marks L, Philp KL, Skinner M, Coker SJ, Currie S. “Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs.” J Pharmacol Toxicol Methods. 2012 Jul;66(1):43-51.
Left Ventricular Pressure
Shen W, Gill RM, Jones BD, Zhang JP, Corbly AK, Steinberg MI. “Combined inotropic and bradycardic effects of a sodium channel enhancer in conscious dogs with heart failure: a mechanism for improved myocardial efficiency compared with dobutamine.” J Pharmacol Exp Ther. 2002 Nov;303(2):673-80.
Gretel Monreal, Mark A Gerhardt, Atsushi Kambara, A.Reza Abrishamchian, John A Bauer, Andrew H Goldstein. “Selective microembolization of the circumflex coronary artery in an ovine model: dilated, ischemic cardiomyopathy and left ventricular dysfunction.” J Card Fail. 2004 Apr;10(2):174-83.
Mondritzki T, Kolkhof P, Sabbah HN, Gheorghiade M, Fürstner C, Schmeck C, Siedentop H, Schaefer S, Truebel H. “Differentiation of arginine vasopressin antagonistic effects by selective V2 versus dual V2/V1a receptor blockade in a preclinical heart failure model.” Am J Ther. 2011 Jan;18(1):31-7.
Mooney L, Marks L, Philp KL, Skinner M, Coker SJ, Currie S. “Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs.” J Pharmacol Toxicol Methods. 2012 Jul;66(1):43-51.
ECG
Gbadebo TD, Trimble RW, Khoo MS, Temple J, Roden DM, Anderson ME. “Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes.” Circulation. 2002 Feb 12;105(6):770-4.
Gutstein DE, Danik SB, Sereysky JB, Morley GE, Fishman GI. “Subdiaphragmatic murine electrophysiological studies: sequential determination of ventricular refractoriness and arrhythmia induction.” Am J Physiol Heart Circ Physiol. 2003 Sep;285(3):H1091-6.
Xiong D, Wang GX, Burkin DJ, Yamboliev IA, Singer CA, Rawat S, Scowen P, Evans R, Ye L, Hatton WJ, Tian H, Keller PS, McCloskey DT, Duan D, Hume JR. “Cardiac-specific overexpression of the human short CLC-3 chloride channel isoform in mice.” Clin Exp Pharmacol Physiol. 2009 Apr;36(4):386-93.
Himmel HM, Hoffmann M. “QTc shortening with a new investigational cancer drug: a brief case study.” J Pharmacol Toxicol Methods. 2010 Jul-Aug;62(1):72-81.
Prado CM, Celes MR, Malvestio LM, Campos EC, Silva JS, Jelicks LA, Tanowitz HB, Rossi MA. “Early dystrophin disruption in the pathogenesis of experimental chronic Chagas cardiomyopathy.” Microbes Infect. 2012 Jan;14(1):59-68.
Mooney L, Marks L, Philp KL, Skinner M, Coker SJ, Currie S. “Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs.” J Pharmacol Toxicol Methods. 2012 Jul;66(1):43-51.
Pressure-Volume Loops
Gretel Monreal, Mark A Gerhardt, Atsushi Kambara, A.Reza Abrishamchian, John A Bauer, Andrew H Goldstein. “Selective microembolization of the circumflex coronary artery in an ovine model: dilated, ischemic cardiomyopathy and left ventricular dysfunction.” J Card Fail. 2004 Apr;10(2):174-83.
Kim HK, Alhammouri MT, Mokhtar YM, Pinsky MR. “Estimating left ventricular contractility using inspiratory-hold maneuvers.” Intensive Care Med. 2007 Jan;33(1):181-9.
Ku HC, Chen WP, Su MJ. “GLP-1 signaling preserves cardiac function in endotoxemic Fischer 344 and DPP4-deficient rats.” Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):463-74.
Blood Flow
Sheriff DD. “Muscle pump function during locomotion: mechanical coupling of stride frequency and muscle blood flow.” Am J Physiol Heart Circ Physiol. 2003 Jun;284(6):H2185-91.
Segreti JA, Polakowski JS, Koch KA, Marsh KC, Bauch JL, Rosenberg SH, Sham HL, Cox BF, Reinhart GA. “Tumor selective antivascular effects of the novel antimitotic compound ABT-751: an in vivo rat regional hemodynamic study.” Cancer Chemother Pharmacol. 2004 Sep;54(3):273-81.
Oishi PE, Wiseman DA, Sharma S, Kumar S, Hou Y, Datar SA, Azakie A, Johengen MJ, Harmon C, Fratz S, Fineman JR, Black SM. “Progressive dysfunction of nitric oxide synthase in a lamb model of chronically increased pulmonary blood flow: a role for oxidative stress.” Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L756-66.
Isolated Heart (Langendorff or Working Heart)
Deussen A, Weichsel J, Pexa A. “Features of adenosine metabolism of mouse heart.” Purinergic Signal. 2006 Nov;2(4):663-8.
Stehr SN, Christ T, Rasche B, Rasche S, Wettwer E, Deussen A, Ravens U, Koch T, Hübler M. “The effects of levosimendan on myocardial function in ropivacaine toxicity in isolated guinea pig heart preparations.” Anesth Analg. 2007 Sep;105(3):641-7.
Himmel HM, Hoffmann M. “QTc shortening with a new investigational cancer drug: a brief case study.” J Pharmacol Toxicol Methods. 2010 Jul-Aug;62(1):72-81.
Action Potential
Perlstein I, Burton DY, Ryan K, Defelice S, Simmers E, Campbell B, Connolly JM, Hoffman A, Levy RJ. “Posttranslational control of a cardiac ion channel transgene in vivo: clarithromycin-hMiRP1-Q9E interactions.” Hum Gene Ther. 2005 Jul;16(7):906-10.
Stehr SN, Christ T, Rasche B, Rasche S, Wettwer E, Deussen A, Ravens U, Koch T, Hübler M. “The effects of levosimendan on myocardial function in ropivacaine toxicity in isolated guinea pig heart preparations.” Anesth Analg. 2007 Sep;105(3):641-7.
Himmel HM, Hoffmann M. “QTc shortening with a new investigational cancer drug: a brief case study.” J Pharmacol Toxicol Methods. 2010 Jul-Aug;62(1):72-81.