Buxco Inhalation Exposure System


Whether your study requires general or precise exposure, the Buxco FinePointe system helps you produce better results in less time.





       

Target AIA in FinePointe 2.9



Nose-Only Inhalation Tower System

  • Produce reproducible results with precise, controlled lung deposition across all subjects with the Accumulated Inhaled Aerosol (AIA) parameter with the addition of plethysmography for collection of respiratory endpoints throughout exposure
  • Get the highest quality data with the Buxco system designed to eliminate rebreathing of CO2 and uniform to all open ports.
  • Cleaning and maintenance is a breeze with the stainless steel, stackable design.
  • Save time by exposing up to 42 subjects simultaneously
Learn more about the benefits of the FinePointe software platform
OneLevel-Tower_small



Mass Dosing

Buxco Mass Dosing Chambers are used to expose multiple subjects to an aerosol or gas when general dosing can be tolerated.  Benefits of the Buxco chambers include:

  • A perforated floor for for urine drainage
  • Removable lid (no seal, should be used inside a containment hood)
  • Two ports for aerosol or gas delivery
  • Four luer ports for bias flow or other use
  • Ability to hold approximately 15 mice, 6 rats or 2 guinea pigs.
    • The Large Mass Dosing Chamber can hold approximately 25 mice, 10 rats or 4 guinea pigs

Mass Dosing system






Single Subject

The Buxco system offers precise nose-only single subject exposure and general exposure through free roaming tubes.

  • Nose-only: a cost effective version of the inhalation tower, enabling uniform exposure one subject at a time. Single Site Exposure Stations are available for mice, rats, and Hartley guinea pigs.
  • Free-Roaming: single subject exposure for general dosing purposes.
     
Single Subject Exposure Station , single subject exposure, inhalation chamber, single subject inhalation
     
inhalation, exposure
     



Smoke Generation and Delivery

Turn-key options to deliver tobacco or vape smoke to subjects via traditional cigarettes, e-cigarettes, or vape devices.

Smoke GeneratorLR

Ecig_LR







Multiple Applications and Derived Parameters With One System

Tower & Plethysmograph Derived Parameters

  • View the Tower Derived Parameters Table

  • View Plethysmograph Derived Parameters







Reference Publications

Bosnjak B, Tilp C, Tomsic C, Dekan G, Pieper M, Erb K, EpsteinM. “Tiotropium bromide inhibits relapsing allergic asthma in BALB/c mice.” Pulmonary Pharmacology and Therapeutics. 2014;27:44-51.

Glynn A, Alves D, Frick O, Erwin-Cohen R, Porter A, Norris S, Waag D, Nalca A. “Comparison of
experimental respiratory tularemia in threenonhuman primate species.” Comparative Immunology, Microbiology and Infectious Diseases. 2015;39:13-24

Haapakoski R, Karisola P, Fyhrquist N, Savinko T, Wolff H, Turjanmaa K, Palosuo T, Reunala T, Lauerma A, Alenius H. “Intradermal cytosine-phosphate-guanosine treatment reduces lung inflammation but induces IFN-gamma-mediated airway hyperreactivity in a murine model of natural rubber latex allergy.” American Journal of Respiratory Cellular and Molecular Biology. 2011;44:639-647.