Buxco Inhalation Exposure System

Whether your study requires general or precise exposure, the Buxco FinePointe system helps you produce better results in less time.

New!: Learn more about subject-specific targeted dosing with SmartStudy

Target AIA in FinePointe 2.9

Nose-Only Inhalation Tower System

Develop reproducible results with precise, controlled lung deposition across all subjects with the Accumulated Inhaled Aerosol (AIA) parameter with the addition of plethysmography for collection of respiratory endpoints throughout exposure
NEW! With SmartStudy, automatically stop delivery of aerosol to single or multiple-dosage groups when they reach their targeted dose
Get the highest quality data with the Buxco system designed to eliminate rebreathing of CO2 and uniform to all open ports
Cleaning and maintenance is a breeze with the stainless steel, stackable design.
Save time by exposing up to 42 subjects simultaneously

Learn more about the benefits of the FinePointe software platform

Flyer DSI Inhalation Efficiency (pdf)

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Flyer Cellular Exposure (pdf)

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NOW AVAILABLE!
Next generation rat restrainer enabling more precise exposure studies, without disruption to your workflow.

- Increase animal comfort and ease of restraint
- Add plethysmography to gain insight into precise inhaled dose
- No changes to SOPs or IACUC approvals required

Optimized rat restrainer

Mass Dosing

Buxco Mass Dosing Chambers are used to expose multiple subjects to an aerosol or gas when general dosing can be tolerated. Benefits of the Buxco chambers include:

A perforated floor for for urine drainage
Removable lid (no seal, should be used inside a containment hood)
Two ports for aerosol or gas delivery
Four luer ports for bias flow or other use
Ability to hold approximately 15 mice, 6 rats or 2 guinea pigs.
- The Large Mass Dosing Chamber can hold approximately 25 mice, 10 rats or 4 guinea pigs

Single Subject

The Buxco system offers precise nose-only single subject exposure and general exposure through free roaming tubes.

Nose-only: a cost effective version of the inhalation tower, enabling uniform exposure one subject at a time. Single Site Exposure Stations are available for mice, rats, and Hartley guinea pigs.
Free-Roaming: single subject exposure for general dosing purposes.

Single Subject Exposure Station , single subject exposure, inhalation chamber, single subject inhalation

Smoke Generation and Delivery

Turn-key options to deliver tobacco or vape smoke to subjects via traditional cigarettes, e-cigarettes, or vape devices.

Multiple Applications and Derived Parameters With One System

Model Development

mouse model

Safety Assessment
Safety pharmacology

Toxicology

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Tower & Plethysmograph Derived Parameters

View the Tower Derived Parameters Table

Parameter	Description	Units
P	Pressure measured within the outer core of the Tower	cmH2O
Tin	Temperature measured at the point where air flow exits the Tower Controller	C
Hin	Humidity measured at the point where air flow exits the Tower Controller	%
Tport	Temperature measured at a Chamber Port	C
Hport	Humidity measure at a Chamber Port	%
Fin	Mass flow rate of air existing the Tower Controller	L/min
Fout	Mass flow rate of air returning to the Tower Controller	L/min
Pbaro	Barometric Pressure measured inside controller	mmHg
Concin	Concentration measured at the Inflow Photometer	mg/m3
Concport	Concentration measured at a Chamber Port Photometer	mg/m3
O2a1	Concentration of O2 from Analyzer Input 1	%
CO2a1	Concentration of CO2 from Analyzer Input 1	%
O2a2	Concentration of O2 from Analyzer Input 2	%
CO2a2	Concentration of CO2 from Analyzer Input 2	%
NebER	Nebulizer efficiency rate as aerosol output
Flow1	Air Flow supplied by Supplemental Flow unit #1	LMP
Flow2	Air Flow supplied by Supplemental Flow unit #2	LMP
Flow3	Air Flow supplied by Supplemental Flow unit #3	LPM
Flow4	Air Flow supplied by Supplemental Flow unit #4	LPM
Flow5	Mass flow rate from Mass Flow Controller
Flow6	Mass flow rate from Mass Flow Controller

View Plethysmograph Derived Parameters

Parameter	Description	Units
f	Frequency - The instantaneous, breath-by-breath rate of breathing	BPM
TV	Tidal Volume - The inspired volume of air per breath. The integral of the negative section of the flow curve	mL or L
MV	Minute Volume - The product of the tidal volume and the respiratory rate, calculated on a breath-by-breath basis	mL/min or L/min
AV	Accumulated Volume - Total volume breathed over a specific period of time. Calculated by adding the TV for each breath to the previous Accumulated Volume. Used in Dosimetry experiments, AV provides a good measure of the actual dose an animal receives.	ml or L
IA	Inhaled Aerosol - The product of the tidal volume and the concentration
AIA	Accumulated Inhaled Aerosol - The sum of the inhaled aerosol values. AIA provides a good measure of the dose an animal receives in a Dosimetry study. If the subject has been used in this study previously, or if a starting AIA has been entered, this parameter will accumulate from that starting value rather than 0.
AD	Accumulated Dose - AIA multiplied by a Deposition Fraction. Deposition Fraction is defaulted to 0.15. Different publications and mathematical models use different Deposition Fractions depending on particle size, so this value can be modified in the Study's Acquisition Algorithm Settings. All subjects assume the same Deposition Fraction.
Cnc	Concentration - Concentration from the photometer placed at a port. Same as Concport and the same for all subjects in the recording.
CncAdj	Adjusted Concentration - Cnc multiplied by the gravimetric correction factor to account for inaccuracies. See the Gravimetric Correction section for more information.
PIF	Peak Inspiratory Flow - The maximum inspiratory flow that occurs in one breath	mL/sec or L/sec
PEF	Peak Expiratory Flow - The maximum expiratory flow that occurs in one breath	mL/sec or L/sec
Penh	Enhanced Pause - An indication of bronchconstriction calculated as ((Te/Rr)-1)(PEFb/PIFb) Where: Te is Expiratory Time Tr is Relaxation Time PEF is Peak Expiratory Flow PIF is Peak Inspiratory Flow
Ti	Inspiratory Time - The time spent inhaling during each breath, from the start of inspiration to the end of inspiration (determined by interpolation of start of expiration). The time flow is negative	Sec
Te	Expiratory Time - The time spent exhaling during each breath, from start of expiration to end of expiration (determined by interpolation back to zero). The time flow is positive	Sec
dV	Delta Volume - The difference between inspiratory and expiratory volume	mL or L
EF50	Expiratory flow at 50% expired volume. An indicator of bronchoconstriction.	mL/sec or L/min
Tr	Relaxation Time -The time it takes for the animal to expire a certain amount of volume	Sec
Rinx	Rejection Index - Calculates the percentage of breaths rejected	%

Reference Publications

Bosnjak B, Tilp C, Tomsic C, Dekan G, Pieper M, Erb K, EpsteinM. “Tiotropium bromide inhibits relapsing allergic asthma in BALB/c mice.” Pulmonary Pharmacology and Therapeutics. 2014;27:44-51.

Glynn A, Alves D, Frick O, Erwin-Cohen R, Porter A, Norris S, Waag D, Nalca A. “Comparison of
experimental respiratory tularemia in threenonhuman primate species.” Comparative Immunology, Microbiology and Infectious Diseases. 2015;39:13-24

Haapakoski R, Karisola P, Fyhrquist N, Savinko T, Wolff H, Turjanmaa K, Palosuo T, Reunala T, Lauerma A, Alenius H. “Intradermal cytosine-phosphate-guanosine treatment reduces lung inflammation but induces IFN-gamma-mediated airway hyperreactivity in a murine model of natural rubber latex allergy.” American Journal of Respiratory Cellular and Molecular Biology. 2011;44:639-647.