Heart Failure

What is Heart Failure?

Heart failure (HF), often referred to as congestive heart failure (CHF), occurs when the heart is unable to provide enough blood pressure to perfuse all of the bodies tissues effectively.  The cardiac insufficiency results in a sequalae of symptoms including shortness of breath, lethargy, and fluid accumulation in lower extremities.  Renal complications are often the result of diuretics prescribed to reduce fluid accumulation.

Common Causes of Heart Failure
  • Coronary artery disease
  • Previous myocardial infarction
  • High blood pressure
  • Atrial fibrillation
  • Valvular heart disease
  • Excess alcohol use
  • Infection
  • Cardiomyopathy of an unknown cause. 


How is Heart Failure Studied?

Due to the complexity of heart failure there are multiple ways to measure or characterize the progression of the disease.  This include echocardiography, measurement of blood pressure, central venous pressure pulmonary artery pressure, left and right ventricular pressures and measuring cardiac dimensions.

Animal models used to study heart failure include mice, rats, rabbits and dogs.  Models are generated by several means, including, genetic selection, induced hypertension and electrical pacing of the heart. 

DSI has solutions for capturing and analyzing bioelectrical and pressure measurements, plus hardwired solutions capable of combining telemetry with other systems such as cardiac dimension measurements. Cardiovascular and respiratory data can be collected and analyzed with the Ponemah Software Platform

Ponemah software, PNM

DSI offers a comprehensive line of telemetry implants capable of measuring cardiovascular endpoints, including blood pressure, left ventricular pressure, ECG, and more in species ranging from mice to swine. 

Learn more about the pressure sensing implants available from DSI.

DSI's digital signal conditioners allow you to collect a wide array of physiologic endpoints, with signal processing that is best in class. Researchers can also integrate hardwired signals with telemetry signals, for even more study flexibility.

Learn more about digital signal conditioners from DSI.

Halcyon WBP - Rat

From basic respiratory measurements in unrestrained and conscious subjects, to more comprehensive and direct, DSI's Buxco respiratory line of products has you covered with a wide range of solutions to use in heart failure studies. 

Learn more about respiratory solutions from DSI.

1860 Heart Failure articles citing DSI in Google Scholar