Mouse RC

FinePointe Resistance and Compliance

DSI’s Buxco® FinePointe Series Resistance and Compliance (RC) sites provide the hardware necessary to collect invasive resistance, dynamic compliance, and elastance data in anesthetized animals. 

The subject is anesthetized and instrumented to directly measure the animal’s respiratory flow and lung pressure. From these direct measurements of the airflow and lung pressure, RI and Cdyn are computed. This system can be used with either tracheostomized or intubated animals. With intubation, you can perform longitudinal studies.


Features

• Continuously measures lung resistance and dynamic compliance in anesthetized animals
• Automated calibration
• Heated bed
• In-line aerosol delivery and control
• Built-in FinePointe console enables control from the site
• Use with intubated animals for longitudinal studies
• Intelligent ventilator supports protocol-driven deep inflations, breath holds and PEEP
• Single USB connection to computer
• Live display and monitoring of the signals and derived data
• Multiple and simultaneous subjects 
• Optional heart rate or blood pressure monitoring
• Optional static compliance measurement available
 

Available for: Mice, Rats, Guinea Pigs


Also available for other species including dogs, monkeys, horses, and swine, using the QT digital preamplifier unit, with a flow transducer, and a pneumotach to measure flow.



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Publications

Bosnjak B, Tilp C, Tomsic C, Dekan G, Pieper M, Erb K, EpsteinM. “Tiotropium bromide inhibits relapsing allergic asthma in BALB/c mice.” Pulmonary Pharmacology and Therapeutics. 2014;27:44-51.

Haapakoski R, Karisola P, Fyhrquist N, Savinko T, Wolff H, Turjanmaa K, Palosuo T, Reunala T, Lauerma A, Alenius H. “Intradermal cytosine-phosphate-guanosine treatment reduces lung inflammation but induces IFN-gamma-mediated airway hyperreactivity in a murine model of natural rubber latex allergy.” American journal of respiratory cellular and molecular biology. 2011;44:639-647.

Lunding L, Webering S, Vock C, Behrends J, Wagner C, Holscher C, Fehrenbach H, Wegmann M. “Poly(inosinic-cytidylic) Acid–Triggered Exacerbation of Experimental Asthma Depends on IL-17A Produced by NK Cells.” Journal of Immunology. 2015;194.

Aparici M, Gavaldà A, Ramos I, Carcasona C, Otal R, Fernández-Blanco J, Montero J, García V, López R, De Alba J, Doe C, Puig C, Vilella D, Miralpeix M. “In vitro and in vivo preclinical profile of abediterol (LAS100977), an inhaled long-acting β2-adrenoceptor agonist, compared with indacaterol, olodaterol and vilanterol.” Journal of Pharmacology. 2016; 770: 961-69.

Ezeamuzie C, El-Hashim A, Renno W, Edafiogho I. “Antiallergic and Antiasthmatic Effects of a Novel Enhydrazinone Ester (CEE-1): Inhibition of Activation of Both Mast Cells and Eosinophils.” Journal of Pharmacology and Experimental Therapeutics. 2014;350:444-454.

Poole J, Wyatt T, Kielian T, Oldenburg P, Gleason A, Bauer A, Golden G, West W, Sisson J, Romberger D. “Toll-like receptor 2 (TLR2) Regulates Organic Dust-Induced Airway Inflammation.” American Journal Respiratory Cellular and Molecular Biology. 2011;45:711-719.

Hatchwell L, Collison A, Girkin J, Parsons K, Li J, Zhang J, Phipps S, Knight D, Bartlett N, Johnston S, Foster P, Wark P, Mattes J. “Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia.” Thorax Online First. 2015.

 

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Resistance and Compliance articles citing DSI in Google Scholar