Buxco® FinePointe Resistance and Compliance

When more advanced endpoints are required, easily add the Buxco Resistance and Compliance (RC) system to your FinePointe platform









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FPRC screenshot




Collect respiratory parameters in anesthetized animals

  • Collect invasive resistance, dynamic compliance, and elastance data
  • Evaluate spontaneously breathing, ventilated, aerosol challenged, and IV challenged animals
    including mice, rats, and guinea pigs 
  • Perform longer data collections with a heated bed
  • Reduce the risk of human error with automated diagnostics and calibration

Rat & GuineaPig RC system_LR





Multiple Applications and Derived Parameters With One System



RC Derived Parameters

  • View List of RC Derived Parameters

Lungs




Publications

Bosnjak B, Tilp C, Tomsic C, Dekan G, Pieper M, Erb K, EpsteinM. “Tiotropium bromide inhibits relapsing allergic asthma in BALB/c mice.” Pulmonary Pharmacology and Therapeutics. 2014;27:44-51.

Haapakoski R, Karisola P, Fyhrquist N, Savinko T, Wolff H, Turjanmaa K, Palosuo T, Reunala T, Lauerma A, Alenius H. “Intradermal cytosine-phosphate-guanosine treatment reduces lung inflammation but induces IFN-gamma-mediated airway hyperreactivity in a murine model of natural rubber latex allergy.” American journal of respiratory cellular and molecular biology. 2011;44:639-647.



2910
Resistance and Compliance articles citing DSI in Google Scholar

Lunding L, Webering S, Vock C, Behrends J, Wagner C, Holscher C, Fehrenbach H, Wegmann M. “Poly(inosinic-cytidylic) Acid–Triggered Exacerbation of Experimental Asthma Depends on IL-17A Produced by NK Cells.” Journal of Immunology. 2015;194.

Aparici M, Gavaldà A, Ramos I, Carcasona C, Otal R, Fernández-Blanco J, Montero J, García V, López R, De Alba J, Doe C, Puig C, Vilella D, Miralpeix M. “In vitro and in vivo preclinical profile of abediterol (LAS100977), an inhaled long-acting β2-adrenoceptor agonist, compared with indacaterol, olodaterol and vilanterol.” Journal of Pharmacology. 2016; 770: 961-69.

Ezeamuzie C, El-Hashim A, Renno W, Edafiogho I. “Antiallergic and Antiasthmatic Effects of a Novel Enhydrazinone Ester (CEE-1): Inhibition of Activation of Both Mast Cells and Eosinophils.” Journal of Pharmacology and Experimental Therapeutics. 2014;350:444-454.

Poole J, Wyatt T, Kielian T, Oldenburg P, Gleason A, Bauer A, Golden G, West W, Sisson J, Romberger D. “Toll-like receptor 2 (TLR2) Regulates Organic Dust-Induced Airway Inflammation.” American Journal Respiratory Cellular and Molecular Biology. 2011;45:711-719.

Hatchwell L, Collison A, Girkin J, Parsons K, Li J, Zhang J, Phipps S, Knight D, Bartlett N, Johnston S, Foster P, Wark P, Mattes J. “Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia.” Thorax Online First. 2015.