The World's First Implantable, Programmable & Refillable Micro Infusion Pump

The iPRECIO® micro infusion pump uses a patented, microprocessor controlled peristalsis mechanism for accurate controlled flow. It is the only implantable and programmable pump for small laboratory animals. iPRECIO® can infuse fluids continuously for as long as six months, and it can be refilled via a percutaneously accessible port.

Request more information on this product.

iPRECIO® is Implantable

iPRECIO® infusion pumps give researchers complete control when administering drugs to freely moving animals. Implanted subcutaneously, iPRECIO eliminates infection risk and reduces animal stress. iPRECIO pumps can be programmed for a variety of protocols and refilled for chronic infusion studies.

iPRECIO® is Programmable

Program complex pharmacokinetic and tolerance based infusion protocols including:

  • constant continuous/variable dose
  • circadian rhythm infusion
  • complex dosage simulations

Further, iPRECIO® enables researchers to test the relevance of dosing time or dosing protocol on the therapeutic index of small and large molecules.

The easy to use menu driven iPRECIO®software header information, along with infusion protocol details, are entered and ultimately downloaded to the pump's flash memory. Start Time, End Time, Flow rate (1.0µl/hour to 30.0µl/hour), Constant and Variable infusion mode are programmable. Both Constant and Variable infusion options have Instant or Recovery Mode Infusion settings.

Programmability makes iPRECIO® pumps indispensable for applications where accurate infusion, recovery/washout periods, constant/variable dose or complex circadian infusion studies are necessary.

Infusion Mode Flow Rate Mode Description
1 Instant Infusion Constant Flow Rate The pump starts administration instantly at the pre-programmed start time & date and continues to infuse for the pre-programmed flow rate and duration.
2 Instant Infusion Variable Flow Rate The pump starts administration instantly at the pre-programmed start time & date and continues to infuse at the various pre-programmed flow rate steps and durations.
3 Post Recovery Infusion Constant Flow Rate The pump starts administration after the animals convalescence period following surgery. During the convalescence/recovery period saline is infused at a programmable constant flow rate. On completion of the recovery period the pump operates as described in instant constant flow rate.
4 Post Recovery Infusion Variable Flow Rate The pump starts administration after the animals convalescence period following surgery. During the convalescence/recovery period saline is infused at a programmable constant flow rate. On completion of the recovery period the pump operates as described in instant variable flow rate.

 

iPRECIO® is Refillable

Implanted infusion models using iPRECIO® can be extended by percutaneous access to the pump refill septum enabling researchers to easily refill the reservoir while in vivo; thus, long-term drug infusion can continue until the battery life has run out or the protocol has ended.

 Additionally, iPRECIO® offers the advantage of having an externally palpable elastic reservoir, providing a physical indicator of pump performance and remaining fluid levels. 

  • Less surgical intervention and extended model life
  • Increased model flexibility by enabling the testing of varying drug concentrations and alternate agents of interest
  • Maximized model use and increased subject welfare

iPRECIO® infusion pumps which are implantable, programmable and refillable will provide benefits of syringe pumps and other implantable pumps combined in one unit. In combination with the physiologic gold standard of telemetry, sophisticated implantable infusion pumps will lead to ever more sensitive and powerful means of detecting drug induced therapeutic and/or adverse effects.