FinePointe Non-Invasive Airway Mechanics
DSI's Buxco® FinePointe Non-Invasive Airway Mechanics (NAM) sites are used to acquire specific airway resistance (sRaw) in conscious subjects. Scientifically established and accepted for over 30 years, this technique measures sRaw by monitoring the phase delay between the nasal and thoracic flows1. This system is ideal for researchers interested in airway resistance without anesthesia.
The subject is restrained in a special chamber which allows for the independent measurement of nasal and thoracic flows. The airway resistance is related to the phase difference between these two flows. This is a direct measurement of airway resistance.
Features
• Continuously measures sRaw in conscious animals
• Automated calibration
• Aerosol delivery and control
• Allay™ chamber design significantly reduces subject loading and acclimation time while providing maximum subject comfort
• Chambers incorporate the patented Halcyon® noise-suppression design
• Scalable for high throughput—easily attach 12 sites to a single computer
• Each USB connection to computer supports 2 to 4 chambers
• Plethysmographs fit onto the same footprint, making it possible to use only one table with several different sizes of plethysmographs
Available for: Mice, Rats, Hartley Guinea Pigs
Also available in the larger, 4-site version.
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1Pennock, B.E., C.P. Cox, R.M. Rogers, W. A. Cain, and J.H. Wells. A noninvasive technique for measurement of changes in specific airway resistance. J. Appl. 46(2): 399-406, 1979.
Publications
Khaitov M, Shilovskiy I, Nikonova A, Shershakova N, Kamyshnikov O, Babakhin A, Zverev V, Johnston S, Khaitov R. “Small interfering RNAs targeted to interleukin-4 and respiratory syncytial virus reduce airway inflammation in a mouse model of virus-induced asthma exacerbation.” Human Gene Therapy. 2014;25:642-650.
Lowe A, Broadley K, Nials A, Ford W, Kidd E. “Adjustment of sensitisation and challenge protocols restores functional and inflammatory responses to ovalbumin in guinea-pigs.” The Journal of Pharmacological and Toxicological Methods. 2014;72: 85-93.
Kandasamy R, Park S, Boyapalle S, Mohapatra S, Hellermann G, Lockey R, Mohapatra S. “Isatin down-regulates expression of atrial natriuretic peptide receptor A and inhibits airway inflammation in a mouse model of allergic asthma.” International Immunopharmacology. 2010;10:218-225.