DSI's new bibliography search tool may help you find publications known to use DSI technology. It is searchable by keyword, title and author and references of interest can be easily exported. The following publications have been included as references to demonstrate how ECG endpoints can be acquired from restrained or freely moving animal models and applied to specific research applications.
Sgoifo, A., et al., “Electrode positioning for reliable telemetry ECG recordings during social stress in unrestrained rats.” Physiology and Behavior. 1996 Mar; 60(6):1397-1401.
London, B., “Cardiac arrhythmias: From (transgenic) mice to men.” J Cardiovascular Electrophysiology. 2001 Sep; 12(9):1089-1091.
Hess, P.,Rey, M., Wanner, D., Steiner, B., Clozel, M., “Measurements of blood pressure and electrocardiogram in conscious freely moving guineapigs: a model for screening QT interval prolongation effects.” Laboratory Animals. 2007 Jan; 41:470-480.
Petric, Clasen, van Weßel, et al., “In vivo electrophysiological characterication of TASK-1 deficient mice.” Cellular Physiology and Biochemistry. 2012.
Hamlin, R. “How many ECG leads are required for in vivo studies in safety pharmacology.” J of Pharmacological and Toxicological Methods. 2008; 57:161-168.
Holzgrefe, H., Cavero, I., Gleason, C., Warner, W., Buchanan, L., Gill, M., Burkett, D., Durham, S., “Novel probabilistic method for precisely correcting the QT interval for heart rate in telemetered dogs and cynomolgus monkeys.” J of Pharmocological and Toxicological Methods. 2006.
Stubhan, M., Markert, M., Mayer, K., et al., “Evaluation of cardiovascular and ECG parameters in normal, freely moving Göttingen minipig.” J Phamacological and Toxicological Methods. 2008 Feb; 57:202-211.
Authier S, Moon LB, Stonerook M, Fournier S, Gervais J, Maghezzi S, Troncy E. “Evaluation of a novel ECG lead placement method in telemetered freely moving cynomolgus monkeys: assessment of an intravascular biopotential lead.” J Phamacological and Toxicological Methods. 2011 Sep-Oct; 64(2):145-150.
Cools, F., et al., “ECG arrhythmias in non-implanted vs. telemetry-implanted dogs: Need for screening before and sufficient recovery time after implantation.” J Pharmacological and Toxicological Methods. 2011.
Prior, H., McMahon, N., Schofield, J., Valentin, J., “Non-invasive telemetric electrocardiogram assessment in conscious beagle dogs.” J Pharmacological and Toxicological Methods. 2009 Jun; 60:167-173.