Support Center


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Join us at the 2020 SPS Virtual Conference to learn about what's happening in the world of Safety Pharmacology. While we are unable to catch-up with you in person, we will be exhibiting virtually and would love to connect and hear about your latest research. 

Not attending the SPS virtual meeting or would like to speak to someone sooner? Click below to schedule a free consultation with us today!

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From in vitro to in vivo, we've got you covered 




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DSI is proud to be a part of the Harvard Bioscience family, who have been providing life science solutions for over 100 years. Multi Channel Systems, our sister brand, offers Safety Pharmacology researchers in vitro electrophysiology solutions for use prior to in vivo studies. Select one of our solutions below from DSI or Multi Channel Systems to learn more about how we can help you expedite and drive reliable results in your next study.  

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In vivo solutions trusted by Safety Pharmacologists throughout the world







In vitro solutions for high-throughput electrophysiology testing

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Highlighted Solutions



  

Cardiopulmonary Large Animal Telemetry
Take the stress out of your daily routine and your data with the L11R cardiopulmonary implant

L11R, cardiopulmonary, cardiopulmonary implant, large animal telemetry

  •  Monitor pressure, biopotential, temperature, respiratory volume, respiratory rate, and activity all in one subject
  • Social housing compatible with a wide range of enclosures
  • Automated configuration eliminates human errors and provides a fast study start-up
  • Encoded animal ID ensures traceability and GLP compliance
  

Power on Detector
(POD2)
The Power on Detector helps you confidently expedite your study set-up providing important PhysioTel Digital implant information.  

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This convenient hand held device is easy to use and will display information such as:

  • Implant ID
  • Serial Number Implant Frequency
  • indicate that an implant has been successfully activated.
  
  
  

Ponemah v5.50
Coming Fall 2020!
Make better decisions with the latest tools optimized to accelerate your safety assessment

Ponemah software 

Ponemah allows researchers to get the best out of each and every study, though custom derived parameters, data cleaning, Data Insights ECG Analysis, and automated SEND output. 

Ponemah v5.50 enhancements include:

  • Centralized License Management
  • Waterfall Plot
  • Improved Protocol Auto Configuration
  • EDF Export for Sensor Data
  • Noldus MediaRecorder 5.0 support
  

MEA Xpress with Multiwell-MEA System
Automated high throughput in vitro electrophysiology for screen experiments

 

Multiwell electrophysiology with automated liquid handling

MCS combined the reliable and cost efficient Opentrons OT-2 pipetting robot with the well known Multiwell-MEA-System to generate an automated platform for substance screening: MEA Xpress.

The robot perfectly houses the 24 and 96 plate Multiwell-MEA-System and offers high-precision pipettes that execute the liquid transfer quickly and accurately.

  


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Case Studies

Visit our Case Studies resource page to learn how DSI solutions helped researchers execute and deliver successful studies.

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Whitepapers

Learn more about how our solutions serve various areas of research by downloading our free whitepapers! Find papers on:

Cardiovascular Biomarkers

Neuroscience

Traumatic Brain Injury

Continuous Glucose Monitoring

Respiratory Diseases

Oncology

 



Webinars

Watch a variety of free, on-demand webinars presented by experts in their field.

 Highlighted Webinar: Combining Telemetry and Ultrasound for Serial Investigation of Cardiovascular Function in Rats

Follow us on Facebook, Twitter, and LinkedIn to get the latest updates from DSI!

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Implantable & External Telemetry




DSI's implants and external telemetry are designed for acquiring data from conscious, freely moving laboratory animals, providing stress-free data collection while enhancing animal welfare. Implantable telemetry and JET are offered in various sizes to support a range of research models, including mice, rats, dogs and non-human primates.

Large Animal Telemetry
Collect cardiovascular, respiratory, CNS, temperature, activity, and more with DSI's full suite of implantable telemetry for large animals

L11R, cardiopulmonary, cardiopulmonary implant, large animal telemetry

Glucose Telemetry
Take your diabetes research to the next level with continuous blood glucose telemetry for small and large animal models

Small Animal Cardiovascular
Collect ECG, single and dual pressure, and more in unrestrained rats 




Pressure and biopotential telemetry implant

Jacketed External Telemetry (JET)
 Harness the power of continuous, real-time data, without the need for surgery


External Telemetry










Software Solutions




Unleash the power of your research with our sophisticated software platforms, trusted by safety pharmacologists around the world to reliably and accurately acquire and analyze physiologic endpoints. Customize your GLP Ponemah environment to your study-specific needs with the addition of smart and powerful modules, like SEND formatting, video, remote connection, and more. 


Respiratory & Inhalation Solutions



See how DSI’s respiratory and inhalation solutions have been utilized this year in covid-19 research.  From precise, homogenous, digital, data-driven compound delivery, to gold standard pulmonary function assessment, DSI offers all-encompassing, turn-key systems.  

Accumulated Inhaled Aerosol (AIA)
By measuring the AIA of each exposed subject, in real-time, critical dose-response relationships can be created utilizing during-exposure respiratory endpoints, as well as post exposure analysis 

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Head-Out Plethysmography
Ideal for researchers interested longitudinal studies without the use of anesthesia.



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  Whole Body Plethysmography
 Measure respiratory function in animals without the use of anesthesia or restraint.



Halcyon WBP - Rat



  

RC System
Measure respiratory resistance and compliance in multiple animals at once for dynamic measurements in anesthetized models


4 Station RCv2
  

Inhalation Systems
Delivery absolute or relative doses of smoke, gases, vapor or compounds through nose only or whole body exposure. Monitor respiratory parameters with plethysmography chambers during dosing and after.

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Hardwired Signals

Still turning knobs? Stop reminding everyone in the lab not to touch the amplifier and confidently collect the analog signals you need using Ponemah's ACQ-7700 digital signal conditioners for stable, accurate calibration and acquisition. Consistent, reliable data acquisition from tethered, acute, or in vitro studies routinely performed in discovery, pharmacology and toxicology laboratories.


Cardiac Electrophysiology

Hemodynamics

Respiratory Signals 

Central Nervous System

Isolated Organs

General Purpose Hardwired System









Scientific Services


Save Time and Money with 
DSI Surgical and Pre-implantable Services

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Experience higher surgical success rates with our flexible menu of surgical options to help you meet your research goals. We can accommodate training and services at your site or ours. Our comprehensive pre-implanted program offers accredited facilities, on-staff veterinarians, and experienced DSI surgeons to deliver healthy, telemetered animals for your research.

Validate with Confidence 


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DSI understands the difficulties you may encounter in GLP Validation and our team is here to help you validate with confidence, speed, and consistency. We can provide master plan templates and test scripts, custom services and consultations, training and certification, and even on-site full service validation packages to help you manage the entire validation process and set you up for success.  

Reach Conclusions Sooner using DSI Data Services

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Managing large amounts of physiologic data can be time consuming and overwhelming. We are ready to help you simplify this process with an experienced team. No matter how complex your research is, we have the tools and expertise to help you successfully reach conclusions. 









Microelectrode Arrays


Microelectrode Array systems are used by Safety Pharmacologists in the last steps right before actual animal experiments, using cells, tissue cultures, or more often with acute slices to investigate drug effects on, for example, synaptic plasticity. Our MEAs record extracellular field potential noninvasively and with high spatial resolution, with the ability to perform long term studies. 

MEA2100 Systems
A versatile system for all applications with 60, 120 or 256 electrodes. 


MEA2100 Mini-Systems
A small footprint system, suitable for use in an incubator, with 60 and 120 electrode options. 

MEA2100-Mini headstage









Multiwell-MEA-Systems


Multiwell systems can be used with neurons or cardiomyocytes both primary, or more recently, from derived stem cells for high throughput to investigate toxicological effects or subtle changes in neuronal activity or cardiac beating behavior.  

Multiwell - MEA - System
Ideal for medium to high throughput electrophysiology, features 288 recording  channels and integrated simulator. For 24 or 96-well plates. 

Multiwell-MEA-System

MEA Xpress
Multiwell electrophysiology with automated liquid handling without user interference. For 24 or 96-well plates. 

MEA Xpress