Buxco Large Animal Whole Body Plethysmography

Dog_chamber_system_side
Large animal respiratory data


WBP is an acronym for Whole Body Plethysmography.  WBP is a way to measure respiratory function in animals (or people) without the use of anesthesia or restraint.  The system relies on a specially designed chamber in which the subject is placed.  A sensitive pressure transducer is connected to measure pressure changes inside the chamber.  Since the chamber is fitted with screen pneumotachs which allow air to pass outside the chamber, the small pressure changes in the chamber are related to flow.  And so, the chamber is a plethysmograph.  From these small flows signals, utilizing special algorithms Buxco FinePointe software derives ventilatory and bronchio constriction parameters.

Key Features

  • Species:  Rabbit, ferret, cat, dog, pig,  NHP*
  • Up to 16 animals can be supported simultaneously
  • Variable bias flow pump provides fresh air supply
  • Digital Preamplifier / controller with USB interface
  • Chambers have integrated pneumotach and reference chamber
  • Flow transducer and optional temperature and humidity probe
  • Integrated nebulizer controller supports Aerogen nebulizer

    *NHP uses chaired resraint

 

Key Benefits

  • Halcyon – Chambers incorporate patented noise suppression design
  • Multiple large animal chamber sizes supported by same hardware, sensors, and software
  • High fidelity differential pressure transducer - provides drift free air flow signal
  • Pre-calibrated digital temperature and humidity probes do not require adjustment
  • FinePointe software integrated study design and subsequent automated reporting
  • Where applicable, standard animal crates are utilized within the chamber for easier animal handling, reduced chamber cleaning, and quicker animal acclimation

Buxco Large Animal WBP Chamber Details

  • View Rabbit / Ferret WBP Chamber

  • View Medium - Large Animal WBP Chamber

  • View Large Animal WBP Chamber

  • View NHP WBP Chamber

WBP Derived Parameters

  • View List of WBP Derived Parameters

Photo Gallery of Whole Body Plethysmography Accessories

A variety of accessories and supplies are available for all Buxco respiratory products to improve system flexibility and maintain proper system performance.  The most commonly requested accessory is the Chamber Maintenance Kit which includes replacement o-ring seals and plethysmograph screens.

Applications & References

Publications citing large animal whole body plethysmography

Katalan S, Falach R, Rosner A, Goldvaser M, Brosh-Nissimov T, Dvir A, Mizrachi A, Goren O, Cohen B, Gal Y, Sapoznikov A, Ehrlich S, Sabo T, Kronman C. “A novel swine model of ricin-induced acute respiratory distress syndrome.” Disease Models & Mechanisms. 2017; 10(2): 173-183.

Lin C, Wu H, Lee J, Liu C. “Functional Phenotype and its Correlation with Therapeutic Response and Inflammatory Type of Bronchoalveolar Lavage Fluid in Feline Lower Airway Disease.” J Vet Inter Med. 2015;29:88-96.

Valente A, Silvestre A, Guasch L, Tort A, Marco I, Lavin S, Cuenca R. “Evaluation of pulmonary function in European land tortoises using whole-body plethysmography.” Veterinary Record. 2012;141:154.

Guasch L, Vadillo A, Grau J, Carreton E, Morchon R, Simon F, Alonso J. “Evaluation of pulmonary function variables by using plethysmography in cats with respiratory disease associated to Dirofilaria immitis.: Veterinary Parasitology. 2012;187:254-258.

Bernaerts F, Talavera J, Leemans J, Hamaide A, Claeys S, Kirschvink N, Clercx C. “Description of original endoscopic findings and respiratory functional assessment using barometric whole-body plethysmography in dogs suffering from brachycephalic airway obstruction syndrome.” The Veterinary Journal. 2010;183:95-102.

1880
Whole body plethysmography articles citing DSI in Google Scholar


Available Chambers (all types)

LA WBP - Key Features
Invasive Non-Invasive
Restrained Un-Restrained*
Acute Longitudinal
Small Animal Large Animal
End Points
Rate / Volumes / Flows
Resistance
Compliance
Lung Characterization
Integrated Drug Delivery Methods
Nebulizer
IV
Tethered Infusion
Common Applications
Asthma
Model Development
Treatment Assessment
Apnea & Breath Scoring
Sleep Apnea
Central Apnea
Sniffs
COPD
Emphysema
Chronic Bronchitis
Lung Fibrosis
Pulmonary Fibrosis
Cystic Fibrosis
Safety Assessment
Safety Pharmacology
Toxicology
Acute Respiratory Disorders
Respiratory Depression
Respiratory Syncytial Virus (RSV)
Acute Respiratory Distress Syndrome (ARDS)
Mucociliary Clearance and Dysfunction
Pneumonia
Cough
Tuberculosis (TB)
Bronchiolitis/ Bronchitis