A World Leader of Behavioral Solutions for Neuroscience Research

Coulbourn Instruments has been providing quality behavioral and physiological research instrumentation to leading scientists worldwide for 40 years. Complete hardware/software integrated systems for in vivo studies in toxicology, pharmacology, and neuroscience for learning and memory, activity, anxiety, addiction, metabolism, contextual fear, acoustic startle, circadian rhythms, drug screening and more.

Highlighted Products

Activity Wheels

The Coulbourn activity wheel mouse cage design was developed in a leading circadian rhythms lab and has been found to be extremely reliable, easy to clean and inexpensive.The wheel is made of stainless steel material and the rotation counting uses a silent magnetic switch. The switch is easily removable for cage cleaning.

Metabolic Monitoring Systems


OxyletPro is a modular system integrating respiratory metabolism, food and drink intake and activity/rearing measurements. This system is optimized for studies in laboratory research models, utilizing indirect calorimetry to evaluate respiratory metabolism. Using a standard rodent home cage, OxyletPro features an airtight lid to ensure the integrity of the sample environment. Independent flow control to each connected cage sends the cage samples in tandem to the gas analyzer for O2 and CO2 concentration analysis.

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Activity and metabolic systems can easily be integrated with DSI technology

Synchronize Voluntary Activity with Ponemah Data

The rodent Activity Wheel represents a very simple and clever way to register animal physical activity in its home cage environment. The use of this high throughput tool is particularly relevant for research involving  circadian rhythms, phenotyping and drug testing. Typically, the time and distance run on a voluntary running wheel are monitored over several days or weeks to determine whether a particular substance or experimental manipulation has an effect on exercise behavior. Running wheel events may be acquired by DSI’s Ponemah software via the Signal Interface solution for synchronized recording with physiological signals, such as activity/sleeping events, body temperature, heart rate, etc. Simply add a light sensor to correlate circadian rhythm with day/night light cycles.


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Monitor Unstressed Physiology during Indirect Calorimetry Studies 

Collect physiology data to better understanding of clusters of conditions and related activity that are often associated with metabolic diseases, hypertension and diabetes. Decreased handling in home cage environments minimizes animal stress and increased translation. Gain a more comprehensive, holistic picture of whole animal cardiovascular and metabolic physiology. 


Discover More Research Solutions Offered by our Sister Companies Below


Animo Acid Analyzers, UV/Visible Spectrophotometers and Microplate Readers


Tools for Improved Measurement of Micro-Volume Sized Samples of DNA, RNA, Oligos and Proteins


 Instruments, Specialty Electrodes and Accessories for Electroporation and Electrofusion


Microdialysis Instruments and Consumables for Basic Research and Optimized, Accelerated Drug Development

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Programmable Syringe Pumps, Pressure and Volume Controlled Ventilators' and Specialized Bioscience Research Products 


Behavioral Research Solutions Including Mazes, Operant Conditioning, Video Tracking, Activity Products and More. 


Instrumentation and Software for Applications in the Fields of Electrophysiology and Electrochemistry

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Premier Supplier of Gel Electrophoresis and Blotting Equipment and Accessories'

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Advanced Isolated Organ and Tissue Perfusion Systems, as well as Data Acquisition Hardware 


Electrophysiology Solutions for In Vitro and In Vivo Recording with Microelectrode Arrays, and Wireless/Tethered In Vivo Recording Systems

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Leader in Value Electrophoresis Systems,   as well as a Comprehensive Range of both Beta and Gamma Radiation Protection Products

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 Biomedical Devices for Electrophysiological, Cellular and Neurological Sciences