Poster Abstract
Studying the circadian rhythms governing physiological processes is vital to understanding their impact on health and diseases. The effect of circadian rhythms on mouse thermoregulation and locomotor activity has been widely studied. However, in experimental settings employing
socially-housed mice, technological restrictions can impose a practical hurdle to investigate the circadian rhythmicity of body temperature and locomotor activity. Current methods used for group-housed mice may present drawbacks in combining high temporal resolution data, long-term data recording capabilities, access to the data in real-time, and device surgical implantability. To address these limitations, we developed a sophisticated telemetry platform, SoHo™, to monitor body temperature and gross locomotor activity in socially housed small animals. Objective: This study aims to validate the SoHo™ telemetry system for simultaneous measurement of core body temperature and gross locomotor activity in group-housed mice.
Objective: This study aims to validate the VivaMARS platform with two reference compounds: caffeine (CAF), known to increase rodent locomotor activity, and chlorpromazine (CPZ), known to decrease rodent locomotor activity.