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DSI Events

WEBINAR, Beyond Traditional Blood Sampling: Enabling Chronic Jugular Microdialysis in Freely Moving Mice


  • Dates: 25 – 25 Mar, 2026

Understanding physiology and behavior requires tools that can capture dynamic biological signals in freely moving animals. While implantable telemetry and behavioral assays provide rich functional data, measuring circulating signaling molecules longitudinally has remained a major technical challenge.

In this webinar, researchers from HHMI Janelia will present a chronic jugular microdialysis workflow that enables continuous sampling of blood chemistry in freely moving mice. Attendees will learn how the method was developed—including surgical approach, probe design iterations, and workflow optimization—and how coupling microdialysis with mass spectrometry enables measurement of hundreds of circulating amines and small peptides over time.

This session will highlight how chronic jugular microdialysis can complement existing telemetry, behavioral, and vascular access approaches, enabling researchers to link molecular dynamics with physiological and behavioral state in ways not previously possible.

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Learning Objectives

By attending this webinar, participants will be able to:

• Explore how longitudinal blood chemistry measurements can reveal physiological state changes and their relationship to behavior

• Understand how chronic jugular microdialysis enables longitudinal measurement of circulating molecules in freely moving animals

• Learn practical considerations for implementing jugular microdialysis, including surgical approach, probe selection, and workflow optimization

• Identify how blood microdialysis can complement implantable telemetry, behavioral monitoring, and other in vivo techniques

• Gain insight into probe development and technical challenges associated with chronic vascular microdialysis

• Evaluate how chronic jugular microdialysis could be applied to their own research in neuroscience, metabolism, pharmacology, or systems physiology

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About DSI Events

Data Sciences International (DSI) is involved in over 60 events every year. These include scientific meetings such as industry trade shows, courses and seminars, workshops, as well as educational user groups and symposia all over the world.

DSI supported educational events are scientific meetings organized in cooperation with a local institution or society, pharmaceutical company, university, or local telemetry user group. Educational event meetings serve as an educational forum in which researchers can freely share current scientific information with their peers, students, and other interested scientists.

Common to the general theme of the meetings is the data collected through physiological monitoring of freely moving conscious laboratory animals made possible through the use of fully implantable telemetry technology.

Presentations and posters on the latest methods employed by the presenting researchers enable those attending to benefit from the as yet unpublished work of peers. Presentations can be on a wide range of related research topics including surgical implantation methods, data analysis methods, treatment effects of new pharmaceutical compounds, new animal models, behavioral and physiological interactions, basic research on physiological systems, and numerous other whole animal chronic monitoring research topics.

Meetings are held in classroom style with ample time allowed for questions and discussion among the participants. Typical audience sizes run from 40 to 120.