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Webinar - Reductions in Impulsivity in an Animal Model of Attention Deficit Hyperactivity Disorder (ADHD)


  • Dates: 23 – 23 Feb, 2021

Join Scott Hall, PhD as he presents his research that focuses on treatments for impulsive behavior commonly associated with Attention Deficit Hyperactivity Disorder (ADHD).

Substantial evidence has shown that dopamine transporter knockout (DAT KO) mice constitute an animal model of Attention Deficit Hyperactivity Disorder (ADHD). DAT -/- mice are hyperactive, show deficits in preattentional processes (e.g. sensorimotor gating), and have impaired executive function. DAT +/- mice show only limited deficits in the same behavioral tests. In examining more complex cognitive tasks using a 5-Choice apparatus, DAT -/- mice were found to be so behaviorally impaired that they could not learn even basic responding. Their attentional focus was solely oriented towards the food panel so that they failed to observe the lights behind them. DAT +/- were capable of learning the task and showed evidence of impulsive behavior in the 5-Choice Continuous Performance Task (5-Choice CPT).

This impulsive behavior was eliminated by treatment with the known ADHD medication atomoxetine, as well as with the putative ADHD treatment SB 224289, a serotonin 5-HT1B antagonist that was previously found to reduce many of the impairments found in DAT -/- mice. These data provide evidence that DAT +/- mice show ADHD like deficits that may provide a better model of ADHD than DAT -/- mice, and further support the potential of 5-HT1B antagonists to reduce impulsive behavior.
F. Scott Hall, ;PhD
F. Scott Hall, PhD
Associate Professor
College of Pharmacy and Pharmaceutical Sciences
University of Toledo


Click here to register for this webinar. 


This webinar is sponsored by Harvard Bioscience and our sister brand Panlab
Panlab S.L.U.Harvard Bioscience, Inc.

 

About DSI Events

Data Sciences International (DSI) is involved in over 60 events every year. These include scientific meetings such as industry trade shows, courses and seminars, workshops, as well as educational user groups and symposia all over the world.

DSI supported educational events are scientific meetings organized in cooperation with a local institution or society, pharmaceutical company, university, or local telemetry user group. Educational event meetings serve as an educational forum in which researchers can freely share current scientific information with their peers, students, and other interested scientists.

Common to the general theme of the meetings is the data collected through physiological monitoring of freely moving conscious laboratory animals made possible through the use of fully implantable telemetry technology.

Presentations and posters on the latest methods employed by the presenting researchers enable those attending to benefit from the as yet unpublished work of peers. Presentations can be on a wide range of related research topics including surgical implantation methods, data analysis methods, treatment effects of new pharmaceutical compounds, new animal models, behavioral and physiological interactions, basic research on physiological systems, and numerous other whole animal chronic monitoring research topics.

Meetings are held in classroom style with ample time allowed for questions and discussion among the participants. Typical audience sizes run from 40 to 120.