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The Value of Continuous Glucose Telemetry

Animal welfare, scientific, and financial benefits can be realized in research applications through the in vivo collection of Continuous Glucose Telemetry data.  This is achieved by providing glucose, temperature, and activity measurements every second for a period of at least four and often six to eight weeks while only requiring one to three blood samples per week. 

Improved Animal Welfare

Continuous glucose telemetry supports the refinement and reduction principles of animal welfare by reducing stress, pain, and the number of animals required for each study.

Higher Quality Data

As the animals are conscious and freely moving, they experience less stress than with traditional restrained methods and the experimental conditions better represent real world outcomes. Continuous data collection with telemetry also provides a more complete picture of results than intermittent sampling. As a result, the data collected is of higher quality and better translates to humans.  

The Value of Continuous Glucose Telemetry

Advanced Study Options

Stress-free, continuous glucose data enables you to perform studies and quantify data in ways not possible or feasible with intermittent sampling. 

  • Use animals sequentially as their own control
  • Detect subtle changes that would otherwise be missed
  • Opportunity for quantification of new and improved biomarkers such as glucose homeostasis, glycemic variability, rate of change to a stimulus, time to an event, time within a range, and more.

Cost Savings

The combination of reduced handling, fewer blood draws, and smaller sample sizes leads to significant savings in labor, consumables, assays, husbandry, test compound, and more.  The reduction in labor allows for application of labor elsewhere helping you to get more done with the same resources.


View our Continuous Glucose Telemetry Brochure to for more information.



Hear from the scientists themselves on how continuous glucose telemetry is enhancing research and providing a more complete picture of glucose levels throughout a study.
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rat glucose

Videos

Interested in learning more about how to use continuous glucose telemetry and its benefits? Check out these videos for more information.





Select Publications

Culler MD, Delale T, Milano S, van der Lely AJ, Abribat T, Clemmons D. (2019). "Impaired glucose homeostasis in leptin-deficient ob/ob mice is corrected by AZP-3404, a 9-amino acid peptide analog derived from insulin-like growth factor-binding protein 2, a key mediator of leptin action". Endocrine Abstracts, 63(OC6.1). https://doi.org/10.1530/endoabs.63.OC6.1

Golic M, Kraker K, Fischer C, Alenina N, Haase N, Herse F, Schutte T, Henrich W, Muller DN, Busjahn A, Bader M, Dechend R. (2018). "Continuous Blood Glucose Monitoring Reveals Enormous Circadian Variations in Pregnant Diabetic Rats". Frontiers in Endocrinology. https://doi.org/10.3389/fendo.2018.00271

Iuchi H, Sakamoto M, Matsutani D, Hirofumi S, Kayama Y, Takeda N, Minamisawa S, Utsunomiya K. (2017). "Time-dependent effects of ipragliflozin on behaviour and energy homeostasis in normal and type 2 diabetic rats: continuous glucose telemetry analysis". Scientific Reports, 7, https://doi.org/10.1038/s41598-017-12106-y

Korstanje R, Ryan JL, Savage HS, Lyons BL, Kane KG, Rizzo SJS. (2017). "Continuous Glucose Monitoring in Female NOD Mice Reveals Daily Rhythms and a Negative Correlation With Body Temperature". Endocrinology, 158(9). https://doi.org/10.1210/en.2017-00266

Martire VL, Valli A, Bingaman MJ, Zoccoli G, Silvani A, Swoap S. (2018). "Changes in blood glucose as a function of body temperature in laboratory mice: implications for daily torpor". Endocrinology and Metabolism, 315(4): E662-E670. https://doi.org/10.1152/ajpendo.00201.2018
 

Visit Google Scholar for additional publication references.






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How could continuous glucose telemetry improve your research?

The value of Continuous Glucose Telemetry is significant but varies based upon both why and how you perform your research. Request a personal evaluation to discuss your application and we will follow up with a summary of potential benefits.

Alternatively, if you would like to initiate contact with our sales organization, schedule a call with us today!


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