通常都采用常用的连线式给药方法给实验动物(主要是大鼠模型)给药。 近年来,随着技术的蓬勃发展,我们可为您提供更加智能化、可程序化控制的自动化给药泵和相关软件平台。
 
DSI与日本PrimeTech公司合作,为您提供 iPRECIO® 全植入式、可程序化控制和能再灌注的给药泵。可全植入小动物皮下,从而给清醒、自由活动(无束缚)状态下的实验动物给药。此外,也能避免传统连线给药方法容易引起的创口感染和应激反应。

iPRECIO® 全植入式给药泵采用专利保护的微型处理器对给药流量进行精准控制,是目前全球唯一的小动物植入式可程序化精准控制的给药泵. iPRECIO® 可长达六个月进行持续给药,也可通过经皮注射入口进行再灌注。

给药与生理信号遥测技术的结合应用

iPRECIO® 给药泵相比于其他注射给药泵或植入式给药泵的优势在于它将全植入式、可程序化精准控制和再灌注等功能结合于一体。将它与DSI遥测技术金标准相结合,精巧的植入式给药泵将为您提供更敏感、更强大的药效探测方法或治疗方案。

iPRECIO® 是一种创新的微型给药泵,采用专利技术精准控制给药量,突破技术局限性。与其它给药泵相比,iPRECIO® 的优势在于可预先设置给药方案,可精准控制或调整给药量,并能经皮再灌注给药泵,从而延长实验周期、获取其它设备或技术无法获取的实验数据 (持续时间取决于流速)

程序化精准控制
研究者可在实验开始前设置给药方案、开始给药和停止给药时间 (以天或具体时间为单位)、可自定义流速、流速模式、给药持续时间、给药模式等。

可通过USB连接线下载完整的实验方案并做好植入前期准备。可支持最大药量为 4.5 – 5.6 毫升,取决于1µL/hr - 30µL/hr范围内的流速。

iPRECIO® 给药流速控制功能包括:

  • 恒定流量模式: 可设置1 – 30 µl/hr的恒定流量
  • 可变流量模式: 可设置多达10种不连续的给药步骤( 1 – 30 µl/hr之间)
  • 还原模式: 如需将术后恢复时间与给药起始时间合并,可通过初始化设置满足您的需求!
  • 重复模式: 适用于制定生理节律、多剂量给药或需剂量反应曲线研究等实验。


体内再灌注

长期给药研究中无需替换空的给药泵,只需经皮再灌注给药泵即可,从而使实验动物免受额外的手术、并能精简动物模型数量。 iPRECIO® 专利管理软件可精准计算可再灌注的流量,便于研究者适时调整和控制,从而以精准的流速给药。

给药与遥测技术结合解决方案

DSI植入子用于监测清醒、自由活动状态下的实验动物生理信号。我们的综合生理信号监测平台有配置灵活和更高数据精准度等优势。遥测技术符合动物福利法规要求,为您精简动物数量、优化实验方案、替代传统需要更多劳动力的试验方法。

将iPRECIO® 给药泵与DSI植入式遥测技术相结合,将帮助研究者更高效地操作实验,并能为以下更多研究领域提高更多可能性:

  • 中枢神经系统
  • 心血管疾病
  • 糖尿病
  • 新药研发
  • 或其它更多领域

领先的技术相结合促进给药技术的应用。研究者可给清醒自由活动状态下的动物模型持续给药和生理信号监测,获取精准数据。无需连线或插管等,达到俩全齐美的效果。


iPRECIO® 适用于大鼠给药实验,可结合DSI遥测技术同时采集遥测数据。
New publications

Imai T., Nakata E., Inoue K.
Inhibition of P2X4 receptor on spinal microglia attenuates mechanical allodynia in experimental autoimmune neuritis rats
Pain Research, Vol. 26 2011, O-59

 
Asemu G., O’Connell K.A., Cox J.W., Dabkowski E.R., Xu W., Ribeiro R.F. Jr., Shekar K.C., Hecker P.A. Rastogi S., Sabbah H.N., Hoppel C.L., and Stanley W.C.
Enhanced Resistance to Permeability Transition in Interfibrillar Cardiac Mitochondria in Dogs: Effects of Aging and Long Term Aldosterone Infusion
Am J Physiol Heart Circ Physiol ajpheart.00674.2012; published ahead of print December 15, 2012, doi:10.1152/ajpheart.00674.2012
http://ajpheart.physiology.org/content/early/2012/12/10/ajpheart.00674.2012.abstract?sid=1c8187a4-b1a5-41e2-9e88-20610af15128

Zaretsky D.V., Zaretskaia M.V., Durant P.J., Rusyniak D.E.
The use of microinfusion pump to perform intrahypothalamic injections in conscious rats.
Neuroscience 2012, New Orleans, USA., October 13th - 17 2012. http://www.abstractsonline.com/Plan/ViewAbstract.aspx?mID=2964&sKey=87d8b951-316f-466a-9eb7-4b154d0bbd2c&cKey=b4b8338f-9bd2-44e2-bcf4-6e05a36cbbcb&mKey=%7b70007181-01C9-4DE9-A0A2-EEBFA14CD9F1%7d

 
Patar, A., Jaafar, H., Jamalullail, S. M. S. S., & Abdullah, J. M.
The body wall crude extract of Stichopus variegatus promotes repair of acute contused spinal cord injury in rats by improving motor function and reduces intramedullary hemorrhage.
Biomed Res, 2012, 23(4), 483.22. http://biomedres.info/yahoo_site_admin/assets/docs/483-494-Jafri_Abdullahll-1.27425644.pdf

 
Sasaki N, Shinjo M, Hirakawa S, Nishinaka M, Tanaka Y, Mawatari K, Kitamori T, Sato K.
A palmtop-sized microfluidic cell culture system driven by a miniaturized infusion pump.
Electrophoresis. 2012 Jul;33(12):1729-35. doi: 10.1002/elps.201100691. http://www.ncbi.nlm.nih.gov/pubmed/22740461

 
Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky D, Majka S, Stenmark KR, Nozik-Grayck E, Bonaventura J, Irwin DC.
Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism.
Am J Physiol Lung Cell Mol Physiol. 2012 Aug;303(4):L312-26. Epub 2012 Jun 22. http://www.ncbi.nlm.nih.gov/pubmed/22728465

 
Yoshinori T., Kenji S., Kazuharu S., and Gozoh T.
Extracellular phosphorylation is a novel target for regenerative medicine against spinal cord injury. The FASEB Journal.
2012;26:921.4,
http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/921.4?sid=8d804f68-eb3f-4c2c-8b12-fa525cbbb359

 
Malicdan MC, Noguchi S, Tokutomi T, Goto Y, Nonaka I, Hayashi YK, and Nishino I.
Peracetylated N-acetylmannosamine, a synthetic sugar molecule, efficiently rescues muscle phenotype and biochemical defects in mouse model of sialic acid-deficient myopathy.
J Biol Chem. 2012 Jan 20; 287(4):2689-705. Epub 2011 Dec 8 http://www.ncbi.nlm.nih.gov/pubmed/22157763

 
Perron J., Frenette V., and Copeman C.
Validation and use of the iPRECIO® Micro Infusion Pump on GLP studies
Society of Toxicology Annual Meeting, San Francisco, United States, March 11th to 14th 2012.
http://www.criver.com/SiteCollectionDocuments/SOT_2012_iPrecio_micro_infusion_pump.pdf

 
Copeman C, Perron J., Trudel Y., Caron S., Emond F., Frenette, and Burr M.
Intraputamenal Infusion in the albino rat
Society of Toxicology Annual Meeting, San Francisco, United States, March 11th to 14th 2012.

 
Wood S.K., McFadden D.V., Grigoriadis D., Bhatnagar S. and Valentino R.J.
Depressive and cardiovascular disease co-morbidity in a rat model of social stress: a putative role for corticotropin-releasing factor
Psychopharmacology 2012 Feb 10. [Epub ahead of print] http://www.ncbi.nlm.nih.gov/pubmed/22322324

 
Clarke I.J., Smith J.T., Henry B.A., Oldfield B.J., Stefanidis A., Millar R.P., Sari I.P., Chng K., Fabre-Nys C., Caraty A., Ang B.T., Chan L., and Fraley G.S.
Gonadotropin-Inhibitory Hormone Is a Hypothalamic Peptide That Provides a Molecular Switch between Reproduction and Feeding.
Neuroendocrinology (DOI: 10.1159/000332822) First published online January 25, 2012.
http://www.ncbi.nlm.nih.gov/pubmed/22286004

 
Kusanagi A., Yamasaki J., Iwatani C., Tsuchiya H. and Torii R.
220 NONHUMAN PRIMATE EMBRYONIC STEM CELLS SIMILAR TO THE BIOLOGICAL PROPERTIES OF MOUSE EMBRYONIC STEM CELLS
Reproduction, Fertility and Development 24(1) 222-222 http://dx.doi.org/10.1071/RDv24n1Ab220


Iwatani C., Yamasaki J., Kusanagi A., Tsuchiya H. and Torii R.
127 Ovarian stimulation in cynomolgus monkeys by a controlled release of follicular-stimulating hormone utilizing a micro infusion pump.
Reproduction, Fertility and Development 24 (1) 176-176 http://dx.doi.org/10.1071/RDv24n1Ab127

 
Tan T., Watts S. W. and Davis R. P.
Drug delivery: enabling technology for drug discovery and development. iPRECIO Micro Infusion Pump: programmable, refillable, and implantable.
Front. Pharmacol. 2:44. doi: 10.3389/fphar.2011.00044 [click here] to access full article on www.frontiersin.org

 
Osborn J., presenter; Fink G., discussant
Implantable infusion pumps for chronic rodent studies.
Workshop: Rodent Instrumentation Workshop M. Knuepfer, Experimental Biology, Washington DC.; April 9th to 13th 2011
http://medschool.slu.edu/pharmphys/uploads/John_Osborn_Implantable_Infusion_Pumps.pdf

 
Yoshinori T.,
Extracellular protein phosphorylation promotes functional recovery from experimental spinal cord injury.
The 6th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects
- Development of Novel Therapy to Specific Disease in organ -, Kyoto, Japan; April 1st and 2nd 2011

 
Schnell C. and Ferrat T.,
Use of novel programmable pump for intracranial administration in an orthotopic glioblastoma tumor model in rats.
DSI User Group Meeting, Paris, France; March 17th 18th 2011

 
Martel E.
Refined rat pharmacology studies with infusion using implantable pumps.
DSI User Group Meeting, Paris, France; March 17th 18th 2011

 
Douglas G., Jones H., Edgington A., Saunders K., Neil Morgan S, Pullen N and Parenty G.
GPR54 agonists a way forward for downregulation of the GnRH pathway?
10th International Symposium on GnRH, Salzburg, Austria, Feb 6th -8th 2011

 
Shobo M., Yamada H., Koakutsu A., Hamada N., Fujii M, Harada K., Ni K., and Matsuoka N.,
Chronic treatment with olanzapine via a novel infusion pump induces adiposity in male rats.
Life Sciences, Volume 88, Issues 17–18, 25 April 2011, Pages 761-765 [ http://www.ncbi.nlm.nih.gov/pubmed/21356217]

 
Chikara Abe, Kunihiko Tanaka, Chihiro Iwata, and Hironobu Morita
Vestibular-mediated increase in central serotonin plays an important role in hypergravity-induced hypophagia in rats
J Appl Physiol, 2010 Sep 16 [Epub ahead of print]; [PubMed Link]

 
Yamato M., Okuyama K., Jin GH., Eguchi A., Watanabe Y., Kataoka Y.
Endogenous IL-1β and IL-1 receptor antagonist in the brain are involved in poly I:C-induced immunological fatigue
The 33rd Annual Meeting of the Japan Neuroscience Society, Kobe, Japan., September 2nd – 4th 2010.

 
Stephanie W. Watts
The Evolving Story of 5-HT and Blood Pressure Mechanisms in a Muddle
Serotonin Club 2010, Montreal, Canada, July 9-11 2010

 
Susan K. Wood
Insights into pharmacotherapy for co-morbid depression and cardiovascular disease using a rodent model of social stress
iPRECIO® Luncheon Seminar, EB2010, Anaheim, United States, April 20-24 2010

 
Patrick Davis, Gregory D Fink, Bridget Seitz, and Stephanie W Watts
Serotonin infusion via the iPrecio® micro infusion pump results in repeated reductions in blood pressure in the normotensive Sprague Dawley rat.
FASEB J. 2010 24:lb551 [Abstract in the FASEB Journal]

 
Jay Gizzi, Theodore Baird, Kyle O'Donohue, Josh Yoder, Jessica Grenwis, and Heather Bogie
Optimization of a fully implantable small animal infusion model involving multi-pressure data collection.
FASEB J. 2010 24:lb571 [Abstract in the FASEB Journal]

 
Shobo M., Yamada H., Koakutsu A., Harada K., Ni K., and Matsuoka N.
Effect of long-term electrical infusion of olanzapine on fat weight in rats: a novel method for administration of biologically and/or chemically fragile compounds.
The 83rd Annual Meeting of the Japanese Pharmacological Society, Osaka, Japan, March 16th -18th 2010

 
Abe C., Tanaka K., Awazu H., Morita H.
The role of the vestibular system on the metabolism under hypergravity environment in rats: Implication for motion sickness.
Neuroscience 2009, Chicago, USA., October 17th - 21st 2009.

 
Yamato M., Okuyama K., Jin GH., Eguchi A., Watanabe Y., Kataoka Y.
Interleukin-1 β expression in the brain is involved in poly I:C-induced immunological fatigue-like behavior in rats
The 32nd Annual Meeting of the Japan Neuroscience Society, Nagoya, Japan., September 16th - 18th 2009.

 
Coles D.I., Warr A., Mead A.
Characterization of Pentobarbital Physical Dependance and Withdrawal in Rats
9th. Safety Pharmacology Society Annual Meeting, Strasbourg, France., September 15th - 18th 2009. http://www.sciencedirect.com/science/article/pii/S1056871910001905

 
Infusion Pumps for Small Laboratory Animals
ALN Magazine May/June 2009
http://www.alnmag.com/article/infusion-pumps-small-laboratory-animals

 
Iwatani C., Yamasaki J., Okahara-Narita J.,Tsuchiya H., Torii R.
Research Center for Animal Life Science Shiga University of Medical Science
Follicular stimulation with micro infusion pump in cynomolgus monkeys (Macaca fascicularis)
The 56th Annual Meeting of the Japanese Association for Laboratory Animal Science 2009, Omiya Sonic City, Japan., May13th - 16th 2009.

 
Abe C, Tashiro T, Tanaka K, Ogihara R, Morita H.
A novel type of implantable and programmable infusion pump for small laboratory animals.
J Pharmacol Toxicol Methods. 2008 Sep 22. [PubMed Link]

 
Emiko Matsuoka, Makoto Miyazaki, Kazunori Iwanaga, and Masao Kakemi.
Assessment of Pharmacokinetic-Pharmacodynamic Relationship of Vitamin B12 in the Treatment of Somnipathy in Rats
14th Annual Meeting of Japanese Society for Chronobiology, Tokyo, Japan, November 7-9 2007


Free Full text articles in Pub Med Central

Administration of Substances to Laboratory Animals
All published 2011.

 
Administration of Substances to Laboratory Animals: Equipment Considerations, Vehicle Selection, and Solute Preparation
Patricia V Turner, Cynthia Pekow, Mary Ann Vasbinder, and Thea Brabb
J Am Assoc Lab Anim Sci. 2011 September; 50(5): 614–627. Published online 2011 September. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189663/?tool=pmcentrez

 
Administration of Substances to Laboratory Animals: Routes of Administration and Factors to Consider
Patricia V Turner, Thea Brabb, Cynthia Pekow, and Mary Ann Vasbinder
J Am Assoc Lab Anim Sci. 2011 September; 50(5): 600–613. Published online 2011 September. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189662/?tool=pmcentrez

 
Drug Delivery: Enabling Technology for Drug Discovery and Development. iPRECIO® Micro Infusion Pump: Programmable, Refillable, and Implantable
Tsung Tan, Stephanie W. Watts, and Robert Patrick Davis
Front Pharmacol. 2011; 2: 44. Published online 2011 July 29. doi: 10.3389/fphar.2011.00044 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3149148/?tool=pmcentrez