Species

Treatment

Seizure/model

Location

Seizure Criteria

SD Rat Pups (Dubé et al., 2015)

Chronic Early Life Stress

Limbic Spontaneous Seizure

Relative to bregma, A/P: -1.6 mm, L: 3.6 mm and V:-8.4 mm (Right Amygdala)

Behavioral phenominom required, spike duration > than 50 msec, and amplitude > 2 fold the background, duration >6 seconds

Nestin-TK transgenic aged mice (Cho et. al, 2013)

Pilocarpine (i.p.)

Acute seizure after brain insult

Relative to bregma, A/P: -2.0 mm, L: 2.2 mm, and A/P 1.0 mm and L: 2.0 mm

>3 Hz bursts of spiking activity, >3 seconds, amplitude > 2 X background, convulsive and non-convulsive, confirmed with video

C57BL/6J mice (Tse et al., 2014)

Kainate (i.p.)

Status Epilepticus

Relative to bregma, A/P: -2.5 mm, L: 2 mm

Behavioral classification (Racine Scale) and power bands

C57BL/6 mice (Weiergräber et al., 2005)

R/S-baclofen (i.p.)

bicucullinemethrobromide

4-AP (i.p.)

Spike/spike wave activity originating from the thalamocortical-corticothhalamic region (R/S baclofen and bicucullinemethrobromide), generalized tonic clonic seizure (4-AP)

Relative to bregma Deep positive lead- A/P: -2mm, L: 2mm (right hemisphere) V: 2 mm (CA3 hippocampus), Negative lead: A/P: - 6.2 mm, L: 0 mm, V: 0 mm

Surface positive lead- A/P: -1 mm, L: 1 mm (right hemisphere), negative lead: A/P: -1 mm, L: 1 mm (left hemisphere)

Not listed

Dunkin Hartley guinea pigs (Crl:HA) (Joosen et al., 2011)

Soman

Organophosphate poisoning

2 stainless steel screws, relative to breagma-A: 8.0 mm, P:1.2 mm, L: 1 mm

Amplitude >3 X of baseline

Beagle Dogs (Dürmüller et al. 2007)

Pentylenetetrazole (PTZ)

Proconvulsant risk

Motor cortex, 2 cm apart and 1 cm from the mid-line

EEG activity of a rhythmic aspect, amplitude clearly exceeding background

Cynomolgus monkeys (Authier et al., 2009)

Pentylenetetrazole (PTZ)

Centrally mediated toxicity

10-20 system, C3-O1, Cz-Oz, C4-O2

Automatic seizure analysis and trained reviewer