Automated Blood Sampler and Telemetry


 AZ ABST Case Study 
 
'ABST' stands for Automated Blood Sampler and Telemetry, the combined solution for integrative pharmacology. Through a collaborative effort between BASi, the maker of the Culex® Automated In Vivo Sampling System, and Data Sciences International (DSI), the gold standard in physiologic monitoring, it is now possible to collect more data from individual animals than ever before. ABST can be used to measure multiple variables in a single animal including heart rate, blood pressure, temperature, blood, urine and feces, dialysates, locomotion, activity and various biopotentials e.g. ECG, EEG, EMG, or ERG. Protocols requiring automated infusion can be easily incorporated and controlled with the BASi system. Contact BASi for further details. 
 
Save Money
This combined system makes it possible to collect multiple streams of data simultaneously from individual animals. The ability to collect blood at the same time as other safety data eliminates the use of satellite groups. Subjects can be re-used after a washout period, leading to further reduction in the use of animals. Since the system is fully automated, it is possible to reduce staff hours compared to traditional methods. Additional money savings arise thanks to better data; the ABST makes it possible to make earlier go/no-go decisions so that money isn’t wasted on compounds that will not make it to market.

Save Time
The ABST system offers full automation for dosing, blood sampling, and the collection of safety data. This allows technicians to use time effectively, for example, an ABST experiment can commence in the morning, followed by a more time consuming manual PK study. Taking this approach can make your staff twice as effective as before. Elimination of satellite groups further reduces the amount of time that is spent on each compound. Finally, early decisions can be made with high quality data, reducing the overall time spent on non-viable compounds.

Gather Better Data
With satellite groups it is difficult to ensure that all study parameters are the same for each group. Indeed, manual pharmacokinetic sampling is often very stressful for research animals, while great care is taken to minimize human intervention during the collection of safety data. The ability to eliminate satellite groups with ABST allows for better control over study variables. Data collection is further refined by achieving a within subject experimental design and capturing inter-animal variability. Additionally, the ABST makes it possible to compare information across organ systems to determine time and exposure-dependent effects. All of these features make it possible to form early and informed decisions during drug development. 
 
With the ABST, it is possible to simultaneously collect:

Urine/Feces for:
  • DMPK
  • Metabonomics
  • Clinical Pathology
Terminal tissue collections for:
  • Clinical Pathology
  • Molecular Toxicology
Other biofluids:
  • Bile
  • Dialysates
Telemetry Data including:
  • Heart Rate
  • Blood Pressure
  • Temperature
  • Locomotion
  • EMG, ERG, ECG or EEG

Serum/Plasma for:
  • DMPK
  • Metabonomics
  • Biomarkers
  • Clinical Pathology
automated blood sampler