Considered one of the most important medical meetings on this subject in the world, the conference includes oral and poster presentations selected from abstracts submitted by clinical and basic researchers, followed by discussions led by leading authorities. With experts in the fields of hypertension and its relationship to cardiac and kidney disease, stroke, obesity, and genetics, attendees will have the opportunity to connect with cross-disciplinary researchers from around the world.

Visit DSI at booth #24 to learn about solutions that will give you confidence in your research data!


Click on the image below to see the location of our booth:




Who's Attending?

                  
Mike Girand                            Lorie Boyd                                 Keith Murphy
Scientific Applications      Account Manager                 Sales Manager (East Region)
Manager


Why DSI? 

• Fully implantable telemetry that collects continuous high quality data
• Acquire data from conscious, freely moving laboratory animals
• Stress-free data collection while reducing risk of infection
• Various sizes to support a range of research models (from mice to non-human primates)
• Knowledgeable and responsive global support team that will ensure you have full confidence with your system and acquiring the data you need for your studies

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DSI Products
DSI products are used in cardiovascular research to study hypertension, cardiometabolism, arrythmias, atherosclerosis, heart failure, MI, stroke, and drug safety, including CNS safety assessment. Some of the biomarkers that can be collected include blood pressure, heart rate, blood glucose, EEG, EMG, heart rate variability, baroreflex, pulse wave velocity, ECG, left ventricular pressure, and many more. 


Cardiovascular
Small Animal 
PhysioTel HD-X and HD-S series telemetry implants are used in small animals such as mice, rats, ferrets or guinea pigs. These implants are capable of measuring pressure, temperature, activity and biopotential signals.  


Large Animal 
PhysioTel Digital M and L series implants are designed for single use or long-term implantation in animals of rabbit size or larger. These implants are capable of measuring pressure, temperature, activity and biopotential signals. 




Metabolism 
The HD XG and M series continuous glucose telemetry implants offer preclinical researchers a novel solution to obtain continuous, real-time, blood glucose, temperature, and activity measurements in laboratory mice, rats and large animals. This solution serves many research areas including diabetes, obesity, and other metabolic diseases, including cardiometabolism.

HD XG for Mice


HD XG for Rats


M series for Large Animals




Ponemah Software

Ponemah software is trusted by hypertension researchers around the world to reliably and accurately acquire and analyze Blood Pressure and ECG endpoints.

BP is used to analyze pressure from the circulatory system and can derive, on a beat-to-beat basis, values for the cardiac cycle such as Systolic, Diastolic, HR, and +/-dP/dt. This type of analysis may be used to determine if an animal model of hypertension has been successfully created, to study the effects and progression of disease and to determine if treatments are effective.

            

ECG computes physiologically meaningful parameters on a beat-to-beat basis, for each cardiac cycle, such as HR, RR-I, QT-I, and QRS width. Researchers interested in hypertension often use ECG measurements to look for potential damage to the heart because of high blood pressure. If collecting BP with ECG, the cross-channel calculation of QA interval may also be measured to assess mechanical vs electrical effects.

Ponemah also offers time and frequency domain HRV analysis. HRV is the physiologic phenomenon of variation in the time interval between heartbeats and is often used in diagnosis of cardiovascular diseases, including hypertension.

The baroreflex is the fastest mechanism to regulate acute blood pressure changes via controlling heart rate, contractility, and peripheral resistance.  The baroreflex or baroreceptor sensitivity (BRS) index is a measurement to quantify how much control the baroreflex has on the heart rate.  BRS can be valuable in assessing the development and progression of cardiovascular diseases such as hypertension. Although Ponemah doesn’t provide a direct BRS calculation, the data necessary to perform the calculations are available for export to Excel for further analysis.

Pulse Wave Velocity (PWV) is an indirect measure of arterial stiffness, and the speed pressure waves travel through the lumen of a blood vessel. In the clinic, a higher pulse wave velocity is correlated with increased vascular stiffening (Hodis, 2011). Increased vascular stiffening is related to multiple cardiovascular diseases. DSI offers dual pressure telemetry solutions that when combined with Ponemah for acquisition and analysis provides highly accurate pulse wave velocity measurements in rats, dogs, NHPs, and other larger animals.

Signal Interface

The new Signal Interface is a flexible, robust solution for acquiring non-telemetric analog or digital signals and synchronizing them with your telemetry data in Ponemah v6.50.  Access the full potential of your data by creating an integrative, comprehensive study when combining telemetry with tools such as:

• Langendorff isolated heart perfusion system
• Pressure catheters
• Blood flow meters
• Running wheels and treadmills
• Stimulus delivery tools
• And more!

CNS Solutions 
Small Animal 

Experience the versatility of recording any combination of two biopotential channels (typically EEG and EMG), plus temperature and activity with the PhysioTel™ HD-X02 and HD-S02.

  

 

Large Animal
Get the data you need by recording any combination of up to four biopotential channels (typically EEG, EMG, or ECG), plus temperature and activity with the PhysioTel™ Digital L03 and L04.

Hardwired Monitoring System for Small Animal
DSI’s hardwired (tethered) solutions provide a minimally invasive method to offer continuous measurement (EEG, EMG, EOG, etc.) during neuroscience studies with small animals.  Tethered solutions allow monitoring of up to 12 EEG/EMG channels per animal.





NeuroScore Software 
After data acquisition has taken place, DSI’s NeuroScore™ software can be used to efficiently analyze chronic data sets common to neuroscience studies.  This modular platform offers sleep scoring, seizure detection, video synchronization, and batch processing capabilities. 

Want to Learn More? 
Click here to learn more about DSI's cardiovascular solutions. 


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