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Infusion That Fits Your Research



IPRECIO close-up with blue reservoir



IMPLANTABLE

PROGRAMMABLE

REFILLABLE




iPRECIO Micro Infusion Pumps




All infusible compounds are not created equal, so why should your infusion methods be? There are lots of available laboratory infusion tools for acute studies, static infusion rates, or tethered infusions, but when you need variable, non-tethered, chronic infusion, perhaps you’ve felt that the options are not so obvious.

We understand that sometimes your research requires infusion tools that can adapt to your study designs. The iPRECIO® Micro Infusion Pump from Primetech Corporation is the world’s first implantable, programmable, refillable infusion pump for mice and other small animals. Combined with top-class support from DSI, with the iPRECIO® Micro Infusion Pump, you have accurate, flexible, chronic infusion delivered just the way you need it.
 

Don’t settle for cookie-cutter infusion. Request more information on this product or contact DSI Client Service today.


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iPRECIO Features

  • iPRECIO® is Implantable

  • iPRECIO® is Programmable

  • iPRECIO® is Refillable



Available Models


iPRECIO SMP-310R for Mice


iPRECIO SMP-200 for Small Animals

iPRECIO Mouse Close up

IPRECIO close-up with blue reservoir






Combine the Power of Telemetry with
High Precision Infusion

IPRECIO System with

A Complete Infusion Telemetry Solution

DSI transmitters are designed to collect and transmit chronic data from conscious freely moving animals. Our comprehensive physiologic monitoring platform provides flexibility and accuracy not available from any other vendor. Telemetric monitoring supports the 3R’s, by reducing animal numbers, refining study design and replacing labor intensive study methods.

Adding telemetry to a chronic infusion protocol using the iPRECIO® infusion pump enables researchers to run better studies and increase the likelihood of new discoveries in various research applications.

Researchers can wirelessly monitor a fully ambulatory infusion model that is chronically delivered test article at accurate rates. The best of both worlds with no wires or tubes.

Free Webinar!
Gold Standard Physiological Monitoring With Novel Infusion Technology: Quality Data in Mice to Marmosets.

Christian Schnell, Lab Head of in-vivo Pharmacology and Oncology Research at Novartis in Basel, Switzerland presents data from multiple species that show how differences in blood pressure, heart rate and acute stress impact drug activity and how dosing a pre-trained animal can influence hemodynamic parameters.




iPrecio Webinar Photo



The Freedom to Deliver Substances During  Behavioral Assessments  







01 IR Actimeter

Rotarod


Optimize Your Behavioral Assessments

Methods to administer agents in animal models typically require restraint, sedation or anesthesia, which can all have an impact on animal behavior. Implantable infusion provides full recovery after initial surgery, allowing the animal to return to normal physiological conditions prior to scheduled or continuous administration. This not only improves animal welfare, it also delivers a positive impact on experimental conditions and relevance of the study results achieved.

Common Applications Include: 
  • PKPD Studies
  • Neurodegenerative Diseases
  • Neuromuscular Disorders
  • Mood Disorders
  • Exercise
  • Addiction 
  • Spinal Cord Injury
  • Circadian Rhythm 




Take the Stress Out of Your Respiratory Data


FP WBP 2-Site System - Mouse


Confidently Measure Respiratory Function in Unstressed, Unrestrained Subjects While Infusing

Whole Body Plethysmography (WBP) is a way to measure respiratory function in animals (or people) without the use of anesthesia or restraint. The system relies on a specially designed chamber in which the subject is placed. A sensitive pressure transducer is connected to measure pressure changes inside the chamber. 

The combination of iPRECIO implantable infusion and WBP allows for the collection of respiratory endpoints before, during and after infusion. This is particularly useful when studying depressive effects of opiates, barbiturates, and certain benzodiazepines, the pulmonary effects caused by chemotherapy, heart medications and antibiotics or treatments for pulmonary conditions such as asthma, pulmonary fibrosis and COPD. 




Infusion Applications and References



With a wide range of compatible solvents and vehicles, iPRECIO Micro Infusion pumps are used as a platform to:

  • Evaluate both non-optimized and optimized compounds
  • Maximize the information content about target engagement (PK/PD)
  • Minimize confounding variables due to stress and human interactions
  • Simulate humanized exposure profiles for translational research 

Below are a list of commonly used applications and direct links to publications using iPRECIO infusion pump technology for in vivo studies. 


CARDIOVASCULAR

Girma Asemu, Kelly A. O'Connell, James W. Cox, Erinne R. Dabkowski, Wenhong Xu, Rogerio F. Ribeiro, Jr, Kadambari C. Shekar, Peter A. Hecker, Sharad Rastogi, Hani N. Sabbah, Charles L. Hoppel, and William C. Stanley. American Journal of Physiology-Heart and Circulatory Physiology 2013 304:4, H514-H528


Intracerebroventricular infusion of donepezil prevents cardiac remodeling and improves the prognosis of chronic heart failure rats
Li, M., Zheng, C., Kawada, T., Inagaki, M., Uemura, K., & Sugimachi, M. (2020). The journal of physiological sciences : JPS, 70(1), 11.



Google Scholar Publications Citing iPrecio +Cardiovascular




NEUROSCIENCE

Spinal Cord Injury - Continuous infusion of PKA and ATP at 1µl/hour for 14 days where solution in pump was changed every 2 days due to stability of PKA and ATP. 
Kenji Suehiro, Yuka Nakamura, Shuai Xu, Youichi Uda, Takafumi Matsumura, Yoshiaki Yamaguchi, Hitoshi Okamura, Toshihide Yamashita & Yoshinori Takei Ecto-domain phosphorylation promotes functional recovery from spinal cord injury Scientific Reports 4 , Article number: 4972 (2014) doi:10.1038/srep04972 
iPRECIO SMP-200 pumps were used to infuse 1µl/hr of artificial CSF intrathecally following surgery and during the recovery period. 
Mitchell D., Read, K., Chapman M. and Patten D. Intrathecal administration using the iPRECIO® implanted pump Development in Life Sciences, Vol 14, No. 4



Google Scholar Publications Citing iPrecio +Neuroscience





METABOLISM

iPRECIO SMP-300 pumps were used to test the potential of ßOHB as a FA signal in mice
Rohit Chavan, Céline Feillet, Sara S. Fonseca Costa, James E. Delorme, Takashi Okabe, Jürgen A.Ripperger & Urs Albrecht Liver-derived ketone bodies are necessary for food anticipation. Nature Communications 7, Article number: 10580 doi:10.1038/ncomms10580
Dosing Profile Profoundly Influences Nicotinic Acid's Ability to Improve Metabolic Control in Rats
Kroon T, Baccega T2, Olsén A, Gabrielsson J, Oakes ND Nicotinic acid timed to feeding reverses tissue lipid accumulation and improves glucose control in obese Zucker rats [S]. J Lipid Res. 2017 Jan; 58 (1): 31-41 Doi: 10.1194 / jlr.M 068395. Epub 2016 Nov 15. 



Google Scholar Publications Citing iPrecio + Metabolism




DRUG DEVELOPMENT

Challenges of intravenous infusion in the juvenile beagle dog
Laure Penard, Karsten Skydsgaard, Christophe Bory, Edward Marsden, Reproductive Toxicology, Volume 72, 2017, Page 46, ISSN 0890-6238


Physiological conditions in iPRECIO® -implanted rats
Masaru Tsuboi, Yoshihide Ueda, Yasufumi Ota, Hiroshi Takehara, Takuya Aoshima, Fukutaro Mizuhashi, Fundamental Toxicological Sciences, 2016, Volume 3, Issue 1, Pages 1-8, Released January 09, 2016, Online ISSN 2189-115X



Google Scholar Publications Citing iPrecio + Drug Development