The combined evaluation of physiology and behavior allows for a complete and comprehensive preclinical assessment. A collaboration between DSI and Noldus made possible a state-of-the-art solution integrating video tracking and telemetric physiologic monitoring. The combined solution enables simultaneous assessment of animal behavior and physiologic analysis in freely moving small animals. Investigating the relationship between physiological and behavioral data can lead to a better understanding of your research results through interactions or responses illustrated by synchronized data.

Noldus Solutions

EthoVision XT
EthoVision XT is an advanced video tracking system, used by researchers and scientist worldwide for different types of behavioral studies, such as locomotor activity tests in an open field wand water maze test. Now GLP compliant environments can also benefit from its outstanding technology.

• One versatile software platform to automate tests in a wide range of set-ups: from lab animals in mazes to farm animals in stables.
• Video tracking technology encompasses state-of-the-art detection methods.
• Subject to continuous research and development by a team of programmers and testers for over fifteen years.

The Observer XT
The Observer XT is the professional and user-friendly event logging software for the collection, analysis, and presentation of observational data.

• Code and describe behavior in an accurate and quantitative way.
• Integrate video and physiology in behavioral studies. 
• Calculate statistics, assess reliability, and create transition matrices. 
• Combine continuous sampling with time sampling.
• Code on-the-go using a handheld with Pocket Observer.

PhenoTyper
PhenoTyper is an instrumented cage to measure and test the behavior of laboratory rodents. It is available in a home cage and a basic cage configuration.

• Full integration of the test environment and video equipment.
• Conduct your experiment independent of light conditions in your lab.
• Standardize your tests.
• Extendable with different add-ons.
• Compatible with EthoVision XT and The Observer XT.
  

DSI Telemetry
Scientists are able to study a number of physiological parameters in laboratory mice and small and large animals using DSI PhysioTel® Transmitters. DSI offers four series of PhysioTel® implantable transmitters to measure different parameters:

• PhysioTel® HD series transmitters measure pressure, biopotentials, temperature and activity in addition to digitally encoded data.
  
  
• PhysioTel® PA series transmitters measure pressure (P) and activity (A) in mice, small animals and large animals.
  
  
• PhysioTel® TA series transmitters measure temperature (T) and activity (A) in mice, small animals and large animals.
  
  
• PhysioTel® EA, CA, ETA and CTA series transmitters measure biopotentials (E, C) such as ECG, EEG and EMG as well as temperature (T) and activity (A) in mice, small animals and large animals.

Moscardo Case Study

Figure 1. The complete Video-tEEG equipment set-up for the simultaneous and continuous recording of videos and telemetric traces from up to 6 singly housed rats. (Moscardo et al (JPTM 2010)

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