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Second Glucose Clamp Seminar


The glucose clamp technique is used for pharmacodynamics studies in anti-diabetes drug development and diagnostic evaluation. The technique involves continuous intravenous infusion of glucose or insulin and glucose combined. Multiple blood samples are required to establish steady state glucose levels. Clamp studies in rodents, however, require specialized skills such as microsurgery and blood sampling. Developments in infusion equipment and glucose sensors as well as refined microsurgical techniques have improved the glucose clamp technique over the years.


With this second seminar we would like to inform you more in depth about the glucose clamp technique in rodents. This year we have workshops on several topics. The focus of this seminar will still be the actual experimental techniques needed for successful clamping; blood sampling technique - acute and chronic-, continuous infusion, continuous glucose measurement and catheterization of blood vessels. On top of that, we strongly believe that bringing you together will improve the glucose clamp technique!

We are pleased to present the following (preliminary) program

09:00 – 09:30   Welcome and Registration

09:30 – 09:45   Seminar Opening, Introduction to the program
                                   Prof. Dr. Martin Hrabe de Angelis, German Mouse Clinic Munich Germany

09:45 – 10:30   The Challenges of Glucose Clamping the Conscious Mouse
                                   Dr. David Wasserman, Vanderbilt Institute, USA

10:30 – 11:00   Dual catheterized mouse model for euglycemic clamping
                                   Dr. Thomas Nielsen, University of Copenhagen, Denmark

11:00 – 11:30   Coffee/tea break

11:30 – 12:15   Systemic phenotyping in search of new mouse models for metabolic disorders in the German Mouse Clinic
                                   Dr. Jan Rozman, German Mouse Clinic Munich, Germany

12:15 – 13:00   Workshops 1, parallel sessions
                                  Methodology of glucose clamp / Tracers in Glucose Clamp

13:00 – 14:00   Lunch

14:00 – 14:30   A Glucose clamp model in rats
                                   Dr. Philip J. Pedersen, Gubra, Denmark

14:30 – 15:15   Workshop 2, parallel sessions
                                   Surgery in mice & rats / Diets in obesity models

15:15 – 15:45   Coffee/tea break

15:45 – 16:30   Development of insulin resistance in a mouse model for type 1 diabetes
                                   Dr. Tomas Jelenik, German Center for Diabetes Research Dusseldorf, Germany

16:30 – 17:15   Continuous glucose telemetry during clamp studies in rats
                                   Dr. Christina Boyle, University of Zurich, Switzerland

17:15 – 17:45   Plenary discussion

19:00                     Dinner in Munich


Registration
Register no later than October 21th, 2016 at http://www.rrssc.eu/index.php

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About DSI Events

Data Sciences International (DSI) is involved in over 60 events every year. These include scientific meetings such as industry trade shows, courses and seminars, workshops, as well as educational user groups and symposia all over the world.

DSI supported educational events are scientific meetings organized in cooperation with a local institution or society, pharmaceutical company, university, or local telemetry user group. Educational event meetings serve as an educational forum in which researchers can freely share current scientific information with their peers, students, and other interested scientists.

Common to the general theme of the meetings is the data collected through physiological monitoring of freely moving conscious laboratory animals made possible through the use of fully implantable telemetry technology.

Presentations and posters on the latest methods employed by the presenting researchers enable those attending to benefit from the as yet unpublished work of peers. Presentations can be on a wide range of related research topics including surgical implantation methods, data analysis methods, treatment effects of new pharmaceutical compounds, new animal models, behavioral and physiological interactions, basic research on physiological systems, and numerous other whole animal chronic monitoring research topics.

Meetings are held in classroom style with ample time allowed for questions and discussion among the participants. Typical audience sizes run from 40 to 120.