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ASM Exhibitor Workshop: Chronic, In Vivo Physiologic Monitoring in Nonhuman Primate and Group-housed Guinea Pig Models to Study Inhalational Melioidosis and Ebola Virus.


  • Dates: 09 – 09 Feb, 2016
  • Location: Hyatt Regency Crystal City - Conference Theatre Room

Presenters:

Anna Honko, Ph.D., NIH/NIAID Integrated Research Facility, Division of Clinical Research, Fort Detrick, MD

Paul Dabisch, Ph.D., National Biodefense Analysis and Countermeasures Center, US Department of Homeland Security

Description:

In vivo monitoring offers new insights into physiologic endpoints explored when characterizing animal models or evaluating the efficacy of medical countermeasures.  Access to this information enables one to possibly identify disease correlates that might predict survival or differences in treatments or refine euthanasia criteria endpoints.  During this one-hour session, Drs. Anna Honko and Paul Dabisch will each present findings from their studies which utilized in vivo physiologic monitoring for ebola virus in a guinea pig model and inhalational melioidosis in a nonhuman primate model, respectively. 

Dr. Anna Honko will discuss outcomes from a proof-of-concept study that involved a blinded comparison of two Ebola virus variants following intraperitoneal (IP) in Hartley guinea pigs using a novel small animal remote temperature monitoring system under biocontainment conditions. Dr. Honko’s study revealed that temperature monitoring with the novel system throughout the study period showed an expected diurnal variability initially, increase in temperature during clinical phase and sharp decline prior to death/euthanasia.

In the second presentation, Dr. Paul Dabisch presents his research on the influence of aerosol particle size on the disease presentation in a nonhuman primate model of inhalational melioidosis in order to better characterize the range of potential disease manifestations that may be possible in natural exposure scenarios. The preliminary results of this study will be discussed, including comparison of fever, cytokine, and bacteremia profiles in animals exposed to large and small particle aerosols, and the utility of time domain indices of heart rate variability as a prognostic biomarker.  

Lunch will be provided.

 

 

About DSI Events

Data Sciences International (DSI) is involved in over 60 events every year. These include scientific meetings such as industry trade shows, courses and seminars, workshops, as well as educational user groups and symposia all over the world.

DSI supported educational events are scientific meetings organized in cooperation with a local institution or society, pharmaceutical company, university, or local telemetry user group. Educational event meetings serve as an educational forum in which researchers can freely share current scientific information with their peers, students, and other interested scientists.

Common to the general theme of the meetings is the data collected through physiological monitoring of freely moving conscious laboratory animals made possible through the use of fully implantable telemetry technology.

Presentations and posters on the latest methods employed by the presenting researchers enable those attending to benefit from the as yet unpublished work of peers. Presentations can be on a wide range of related research topics including surgical implantation methods, data analysis methods, treatment effects of new pharmaceutical compounds, new animal models, behavioral and physiological interactions, basic research on physiological systems, and numerous other whole animal chronic monitoring research topics.

Meetings are held in classroom style with ample time allowed for questions and discussion among the participants. Typical audience sizes run from 40 to 120.